Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum

D.M. Remus

Research output: Thesisinternal PhD, WU

Abstract

Probiotics are health-promoting microorganisms that exert their beneficial effects in several ways. While it is known that probiotic bacteria interact with cells of the host gastrointestinal tractand modulate cell-signaling responses by which they might promote health, the underlying molecular mechanism and probiotic “effector” molecules that are responsible for these effects remain largely unexplored. In this thesis, effector molecules of the lactic acid bacterium Lactobacillus plantarum were discovered that interact with diverse host cell types and manipulate cell-associated signaling pathways. This work represents crucial steps to better understand the exact mode of probiotic action, which is a prerequisite for their controlled, safe, purpose-directed, and person-specific applications in the context of health improvement and disease prevention.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Kleerebezem, Michiel, Promotor
  • Bron, P.A., Co-promotor
Award date9 Oct 2012
Place of PublicationS.l.
Publisher
Print ISBNs9789461733733
Publication statusPublished - 2012

Fingerprint

Lactobacillus plantarum
Probiotics
Health
Bacteria
Lactic Acid

Keywords

  • lactobacillus plantarum
  • probiotics
  • genomics
  • host pathogen interactions

Cite this

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title = "Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum",
abstract = "Probiotics are health-promoting microorganisms that exert their beneficial effects in several ways. While it is known that probiotic bacteria interact with cells of the host gastrointestinal tractand modulate cell-signaling responses by which they might promote health, the underlying molecular mechanism and probiotic “effector” molecules that are responsible for these effects remain largely unexplored. In this thesis, effector molecules of the lactic acid bacterium Lactobacillus plantarum were discovered that interact with diverse host cell types and manipulate cell-associated signaling pathways. This work represents crucial steps to better understand the exact mode of probiotic action, which is a prerequisite for their controlled, safe, purpose-directed, and person-specific applications in the context of health improvement and disease prevention.",
keywords = "lactobacillus plantarum, probiotica, genomica, gastheer-pathogeen interacties, lactobacillus plantarum, probiotics, genomics, host pathogen interactions",
author = "D.M. Remus",
note = "WU thesis 5325",
year = "2012",
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isbn = "9789461733733",
publisher = "s.n.",
school = "Wageningen University",

}

Remus, DM 2012, 'Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum', Doctor of Philosophy, Wageningen University, S.l..

Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum. / Remus, D.M.

S.l. : s.n., 2012. 187 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum

AU - Remus, D.M.

N1 - WU thesis 5325

PY - 2012

Y1 - 2012

N2 - Probiotics are health-promoting microorganisms that exert their beneficial effects in several ways. While it is known that probiotic bacteria interact with cells of the host gastrointestinal tractand modulate cell-signaling responses by which they might promote health, the underlying molecular mechanism and probiotic “effector” molecules that are responsible for these effects remain largely unexplored. In this thesis, effector molecules of the lactic acid bacterium Lactobacillus plantarum were discovered that interact with diverse host cell types and manipulate cell-associated signaling pathways. This work represents crucial steps to better understand the exact mode of probiotic action, which is a prerequisite for their controlled, safe, purpose-directed, and person-specific applications in the context of health improvement and disease prevention.

AB - Probiotics are health-promoting microorganisms that exert their beneficial effects in several ways. While it is known that probiotic bacteria interact with cells of the host gastrointestinal tractand modulate cell-signaling responses by which they might promote health, the underlying molecular mechanism and probiotic “effector” molecules that are responsible for these effects remain largely unexplored. In this thesis, effector molecules of the lactic acid bacterium Lactobacillus plantarum were discovered that interact with diverse host cell types and manipulate cell-associated signaling pathways. This work represents crucial steps to better understand the exact mode of probiotic action, which is a prerequisite for their controlled, safe, purpose-directed, and person-specific applications in the context of health improvement and disease prevention.

KW - lactobacillus plantarum

KW - probiotica

KW - genomica

KW - gastheer-pathogeen interacties

KW - lactobacillus plantarum

KW - probiotics

KW - genomics

KW - host pathogen interactions

M3 - internal PhD, WU

SN - 9789461733733

PB - s.n.

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