Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2

A.A. Dihal, R.A. Woutersen, B. van Ommen, I.M.C.M. Rietjens, R.H. Stierum

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Abstract

The effect of the dietary flavonoid quercetin was investigated on proliferation and differentiation of the human colon cancer cell line Caco-2. Confluent Caco-2 monolayers exposed to quercetin showed a biphasic effect on cell proliferation and a decrease in cell differentiation (0.001
Original languageEnglish
Pages (from-to)248-259
JournalCancer Letters
Volume238
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • colon-cancer cells
  • estrogen-receptor
  • in-vitro
  • dietary flavonoids
  • absorption
  • expression
  • metabolism
  • glycosides
  • genistein
  • apoptosis

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