Modulators of human epithelial sodium channels (hENaC)

M.M. van Oers (Inventor), J.M. Vlak (Inventor), E.W. Tareilus (Inventor)

Research output: Patent


An assay method for the isolation of compounds that alter the human ENaC epithelial ion channel activity comprising: (i) preparing an expression system comprising human a -, b -, and q -subunits; (ii) adding a test compound to the expression system and: (iii) determining if there is a change in hENaC ion channel activity resulting from the addition of the test compound. Also claimed is a gene cassette under the control of a promoter and a transfer vector both comprising the three subunits above.
Original languageEnglish
Patent numberGB2396414
Publication statusPublished - 23 Jun 2004


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