An assay method for the isolation of compounds that alter the human ENaC epithelial ion channel activity comprising: (i) preparing an expression system comprising human a -, b -, and q -subunits; (ii) adding a test compound to the expression system and: (iii) determining if there is a change in hENaC ion channel activity resulting from the addition of the test compound. Also claimed is a gene cassette under the control of a promoter and a transfer vector both comprising the three subunits above.
|Publication status||Published - 23 Jun 2004|
van Oers, M. M., Vlak, J. M., & Tareilus, E. W. (2004). Modulators of human epithelial sodium channels (hENaC). (Patent No. GB2396414). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=GB&NR=2396414A&KC=A&FT=D&ND=3&date=20040623&DB=&locale=en_EP#