Modification of flavonoid biosynthesis in crop plants

    Research output: Contribution to journalArticleAcademicpeer-review

    272 Citations (Scopus)

    Abstract

    Flavonoids comprise the most common group of polyphenolic plant secondary metabolites. In plants, flavonoids play an important role in biological processes. Beside their function as pigments in flowers and fruits, to attract pollinators and seed dispersers, flavonoids are involved in UV-scavenging, fertility and disease resistance. Since they are present in a wide range of fruits and vegetables, flavonoids form an integral part of the human diet. Currently there is broad interest in the effects of dietary polyphenols on human health. In addition to the potent antioxidant activity of many of these compounds in vitro, an inverse correlation between the intake of certain polyphenols and the risk of cardiovascular disease, cancer and other age related diseases has been observed in epidemiological studies. The potential nutritional effects of these molecules make them an attractive target for genetic engineering strategies aimed at producing plants with increased nutritional value. This review describes the current knowledge of the molecular regulation of the flavonoid pathway and the state of the art with respect to metabolic engineering of this pathway in crop plants. Keywords: Flavonoids; Genetic modification; Crop; Plant species
    Original languageEnglish
    Pages (from-to)2631-2648
    JournalPhytochemistry
    Volume65
    Issue number19
    DOIs
    Publication statusPublished - 2004

    Fingerprint

    Biosynthesis
    Flavonoids
    Crops
    flavonoids
    biosynthesis
    crops
    polyphenols
    Polyphenols
    Fruits
    genetic engineering
    Fruit
    Metabolic engineering
    Metabolic Engineering
    Biological Phenomena
    Genetic engineering
    metabolic engineering
    Disease Resistance
    fruits
    Genetic Engineering
    Scavenging

    Keywords

    • stilbene synthase gene
    • signal-transduction pathways
    • lc regulatory gene
    • vitis-vinifera l.
    • flower color
    • chalcone synthase
    • anthocyanin biosynthesis
    • petunia-hybrida
    • male-sterility
    • maize lc

    Cite this

    @article{4bae78ff89894857902c734806a2c513,
    title = "Modification of flavonoid biosynthesis in crop plants",
    abstract = "Flavonoids comprise the most common group of polyphenolic plant secondary metabolites. In plants, flavonoids play an important role in biological processes. Beside their function as pigments in flowers and fruits, to attract pollinators and seed dispersers, flavonoids are involved in UV-scavenging, fertility and disease resistance. Since they are present in a wide range of fruits and vegetables, flavonoids form an integral part of the human diet. Currently there is broad interest in the effects of dietary polyphenols on human health. In addition to the potent antioxidant activity of many of these compounds in vitro, an inverse correlation between the intake of certain polyphenols and the risk of cardiovascular disease, cancer and other age related diseases has been observed in epidemiological studies. The potential nutritional effects of these molecules make them an attractive target for genetic engineering strategies aimed at producing plants with increased nutritional value. This review describes the current knowledge of the molecular regulation of the flavonoid pathway and the state of the art with respect to metabolic engineering of this pathway in crop plants. Keywords: Flavonoids; Genetic modification; Crop; Plant species",
    keywords = "stilbene synthase gene, signal-transduction pathways, lc regulatory gene, vitis-vinifera l., flower color, chalcone synthase, anthocyanin biosynthesis, petunia-hybrida, male-sterility, maize lc",
    author = "E.G.W.M. Schijlen and {de Vos}, C.H. and {van Tunen}, A.J. and A.G. Bovy",
    year = "2004",
    doi = "10.1016/j.phytochem.2004.07.028",
    language = "English",
    volume = "65",
    pages = "2631--2648",
    journal = "Phytochemistry",
    issn = "0031-9422",
    publisher = "Elsevier",
    number = "19",

    }

    Modification of flavonoid biosynthesis in crop plants. / Schijlen, E.G.W.M.; de Vos, C.H.; van Tunen, A.J.; Bovy, A.G.

    In: Phytochemistry, Vol. 65, No. 19, 2004, p. 2631-2648.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Modification of flavonoid biosynthesis in crop plants

    AU - Schijlen, E.G.W.M.

    AU - de Vos, C.H.

    AU - van Tunen, A.J.

    AU - Bovy, A.G.

    PY - 2004

    Y1 - 2004

    N2 - Flavonoids comprise the most common group of polyphenolic plant secondary metabolites. In plants, flavonoids play an important role in biological processes. Beside their function as pigments in flowers and fruits, to attract pollinators and seed dispersers, flavonoids are involved in UV-scavenging, fertility and disease resistance. Since they are present in a wide range of fruits and vegetables, flavonoids form an integral part of the human diet. Currently there is broad interest in the effects of dietary polyphenols on human health. In addition to the potent antioxidant activity of many of these compounds in vitro, an inverse correlation between the intake of certain polyphenols and the risk of cardiovascular disease, cancer and other age related diseases has been observed in epidemiological studies. The potential nutritional effects of these molecules make them an attractive target for genetic engineering strategies aimed at producing plants with increased nutritional value. This review describes the current knowledge of the molecular regulation of the flavonoid pathway and the state of the art with respect to metabolic engineering of this pathway in crop plants. Keywords: Flavonoids; Genetic modification; Crop; Plant species

    AB - Flavonoids comprise the most common group of polyphenolic plant secondary metabolites. In plants, flavonoids play an important role in biological processes. Beside their function as pigments in flowers and fruits, to attract pollinators and seed dispersers, flavonoids are involved in UV-scavenging, fertility and disease resistance. Since they are present in a wide range of fruits and vegetables, flavonoids form an integral part of the human diet. Currently there is broad interest in the effects of dietary polyphenols on human health. In addition to the potent antioxidant activity of many of these compounds in vitro, an inverse correlation between the intake of certain polyphenols and the risk of cardiovascular disease, cancer and other age related diseases has been observed in epidemiological studies. The potential nutritional effects of these molecules make them an attractive target for genetic engineering strategies aimed at producing plants with increased nutritional value. This review describes the current knowledge of the molecular regulation of the flavonoid pathway and the state of the art with respect to metabolic engineering of this pathway in crop plants. Keywords: Flavonoids; Genetic modification; Crop; Plant species

    KW - stilbene synthase gene

    KW - signal-transduction pathways

    KW - lc regulatory gene

    KW - vitis-vinifera l.

    KW - flower color

    KW - chalcone synthase

    KW - anthocyanin biosynthesis

    KW - petunia-hybrida

    KW - male-sterility

    KW - maize lc

    U2 - 10.1016/j.phytochem.2004.07.028

    DO - 10.1016/j.phytochem.2004.07.028

    M3 - Article

    VL - 65

    SP - 2631

    EP - 2648

    JO - Phytochemistry

    JF - Phytochemistry

    SN - 0031-9422

    IS - 19

    ER -