TY - JOUR
T1 - Moderate coffee consumption is associated with a less rapid cognitive decline in elderly men: the FINE study
AU - van Gelder, B.M.
AU - Buijsse, G.M.
AU - Kalmijn, S.
AU - Tijhuis, M.J.
AU - Giampaoli, S.
AU - Nissinen, A.
AU - Kromhout, D.
PY - 2004
Y1 - 2004
N2 - Coffee is a daily consumed drink in most Western countries
and is the primary source of caffeine. Caffeine intake seems to be beneficial
for cognitive function on the short term, however results are controversial
and longitudinal information on this association is lacking. Objective(s):
This study investigated whether coffee consumption is associated with 10-
year age-related cognitive decline in elderly men. Methods: Seven hundred
and seven healthy men born between 1900 and 1920 of Finland, Italy
and the Netherlands participated in this longitudinal study between 1990
and 2000. Cognitive functioning was assessed using the Mini Mental State
Examination (MMSE). The maximum score on the MMSE is 30 points, with
a higher score indicating better cognitive performance. Coffee consumption
was estimated in cups per day. A mixed longitudinal random coefficient
model was used to determine the association between baseline coffee
consumption and 10-year cognitive decline. Adjustments were made for the
potential confounding factors age, education, alcohol consumption, smoking
status, serum cholesterol, cohort, anti-hypertensive drug use, anticoagulant
use, body mass index, physical activity and baseline cognitive functioning
(if applicable). Results: Cognitive functioning did not differ between coffee
consumers and non-consumers in 1990. However, men who did not drink
coffee had a 10 year cognitive decline of 2.5 points (8.3%), which is stronger
(p <0.05) than the cognitive decline of men who did drink one to four
cups of coffee a day. Men who consumed three cups of coffee a day had
the least cogllitive decline of 0.6 points (2.0%), which was 4.2 times less
rapid than men who did not drink coffee (p <0.001). The cognitive decline
of men who consumed more than four cups of coffee per day did not differ
from men who did not drink coffee. Conclusions: Our findings suggest that
drinking 1-4 cups of coffee a day may reduce cognitive decline in elderly
men. However, confirmation by other longitudinal studies is necessary.
AB - Coffee is a daily consumed drink in most Western countries
and is the primary source of caffeine. Caffeine intake seems to be beneficial
for cognitive function on the short term, however results are controversial
and longitudinal information on this association is lacking. Objective(s):
This study investigated whether coffee consumption is associated with 10-
year age-related cognitive decline in elderly men. Methods: Seven hundred
and seven healthy men born between 1900 and 1920 of Finland, Italy
and the Netherlands participated in this longitudinal study between 1990
and 2000. Cognitive functioning was assessed using the Mini Mental State
Examination (MMSE). The maximum score on the MMSE is 30 points, with
a higher score indicating better cognitive performance. Coffee consumption
was estimated in cups per day. A mixed longitudinal random coefficient
model was used to determine the association between baseline coffee
consumption and 10-year cognitive decline. Adjustments were made for the
potential confounding factors age, education, alcohol consumption, smoking
status, serum cholesterol, cohort, anti-hypertensive drug use, anticoagulant
use, body mass index, physical activity and baseline cognitive functioning
(if applicable). Results: Cognitive functioning did not differ between coffee
consumers and non-consumers in 1990. However, men who did not drink
coffee had a 10 year cognitive decline of 2.5 points (8.3%), which is stronger
(p <0.05) than the cognitive decline of men who did drink one to four
cups of coffee a day. Men who consumed three cups of coffee a day had
the least cogllitive decline of 0.6 points (2.0%), which was 4.2 times less
rapid than men who did not drink coffee (p <0.001). The cognitive decline
of men who consumed more than four cups of coffee per day did not differ
from men who did not drink coffee. Conclusions: Our findings suggest that
drinking 1-4 cups of coffee a day may reduce cognitive decline in elderly
men. However, confirmation by other longitudinal studies is necessary.
M3 - Abstract
VL - 25
SP - S481
JO - Neurobiology of aging
JF - Neurobiology of aging
SN - 0197-4580
IS - S2
ER -