Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity

J.W.J. Beulens, R. van den Berg, F.J. Kok, A. Helander, S.H.F. Vermunt, H.F.J. Hendriks

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22 Citations (Scopus)


Background and aims To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI. Methods and results Eleven lean (BMI: 18.5¿25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p <0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5). An interaction between BMI and treatment (p <0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only. Conclusion Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people.
Original languageEnglish
Pages (from-to)539-544
JournalNutrition, Metabolism & Cardiovascular Diseases
Issue number8
Publication statusPublished - 2008


  • gamma-glutamyl-transferase
  • coronary-heart-disease
  • c-reactive protein
  • middle-aged men
  • postmenopausal women
  • risk-factors
  • randomized intervention
  • cardiovascular-disease
  • insulin sensitivity
  • serum paraoxonase

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