Modelling the effect of gene deployment strategies on durability of plant resistance under selection

Marjolein E. Lof*, Wopke van der Werf

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Genetic resistance in crop plants is a cornerstone of disease management in agriculture. Such genetic resistance is often rapidly overtaken due to selection in the pathogen population, resulting in an arms race between plant breeders and the pathogen population. Here we ask whether there are strategies that can prolong the useful life of plant resistance genes. In a modelling study we compare three basic strategies: gene pyramiding, sequential use, and simultaneous use, and combinations of these. We furthermore explore the effects of fraction of host area, fraction of resistant host and the threshold fraction of virulence in the pathogen population at which resistance is considered overtaken on the useful life of resistance genes. We found that pyramiding is not always the most durable solution. Model results indicate that the most durable deployment strategy depends on the threshold fraction at which resistance is considered overtaken. This threshold fraction will depend on the economic value of the crop, and whether damage is acceptable. Pyramiding is only the most durable solution if the threshold is low. Otherwise, simultaneous use of single-gene resistant varieties is the most durable solution.
Original languageEnglish
Pages (from-to)10-17
JournalCrop Protection
Volume97
DOIs
Publication statusPublished - 2017

Fingerprint

durability
genetic resistance
pathogens
genes
plant breeders
crops
economic valuation
disease control
virulence
agriculture

Keywords

  • Propagule dispersal
  • Pyramiding
  • Sequential use
  • Simultaneous use
  • Useful life

Cite this

@article{3511da6d436444d4a1d265f4bade87d1,
title = "Modelling the effect of gene deployment strategies on durability of plant resistance under selection",
abstract = "Genetic resistance in crop plants is a cornerstone of disease management in agriculture. Such genetic resistance is often rapidly overtaken due to selection in the pathogen population, resulting in an arms race between plant breeders and the pathogen population. Here we ask whether there are strategies that can prolong the useful life of plant resistance genes. In a modelling study we compare three basic strategies: gene pyramiding, sequential use, and simultaneous use, and combinations of these. We furthermore explore the effects of fraction of host area, fraction of resistant host and the threshold fraction of virulence in the pathogen population at which resistance is considered overtaken on the useful life of resistance genes. We found that pyramiding is not always the most durable solution. Model results indicate that the most durable deployment strategy depends on the threshold fraction at which resistance is considered overtaken. This threshold fraction will depend on the economic value of the crop, and whether damage is acceptable. Pyramiding is only the most durable solution if the threshold is low. Otherwise, simultaneous use of single-gene resistant varieties is the most durable solution.",
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author = "Lof, {Marjolein E.} and {van der Werf}, Wopke",
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Modelling the effect of gene deployment strategies on durability of plant resistance under selection. / Lof, Marjolein E.; van der Werf, Wopke.

In: Crop Protection, Vol. 97, 2017, p. 10-17.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Modelling the effect of gene deployment strategies on durability of plant resistance under selection

AU - Lof, Marjolein E.

AU - van der Werf, Wopke

PY - 2017

Y1 - 2017

N2 - Genetic resistance in crop plants is a cornerstone of disease management in agriculture. Such genetic resistance is often rapidly overtaken due to selection in the pathogen population, resulting in an arms race between plant breeders and the pathogen population. Here we ask whether there are strategies that can prolong the useful life of plant resistance genes. In a modelling study we compare three basic strategies: gene pyramiding, sequential use, and simultaneous use, and combinations of these. We furthermore explore the effects of fraction of host area, fraction of resistant host and the threshold fraction of virulence in the pathogen population at which resistance is considered overtaken on the useful life of resistance genes. We found that pyramiding is not always the most durable solution. Model results indicate that the most durable deployment strategy depends on the threshold fraction at which resistance is considered overtaken. This threshold fraction will depend on the economic value of the crop, and whether damage is acceptable. Pyramiding is only the most durable solution if the threshold is low. Otherwise, simultaneous use of single-gene resistant varieties is the most durable solution.

AB - Genetic resistance in crop plants is a cornerstone of disease management in agriculture. Such genetic resistance is often rapidly overtaken due to selection in the pathogen population, resulting in an arms race between plant breeders and the pathogen population. Here we ask whether there are strategies that can prolong the useful life of plant resistance genes. In a modelling study we compare three basic strategies: gene pyramiding, sequential use, and simultaneous use, and combinations of these. We furthermore explore the effects of fraction of host area, fraction of resistant host and the threshold fraction of virulence in the pathogen population at which resistance is considered overtaken on the useful life of resistance genes. We found that pyramiding is not always the most durable solution. Model results indicate that the most durable deployment strategy depends on the threshold fraction at which resistance is considered overtaken. This threshold fraction will depend on the economic value of the crop, and whether damage is acceptable. Pyramiding is only the most durable solution if the threshold is low. Otherwise, simultaneous use of single-gene resistant varieties is the most durable solution.

KW - Propagule dispersal

KW - Pyramiding

KW - Sequential use

KW - Simultaneous use

KW - Useful life

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JF - Crop Protection

SN - 0261-2194

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