Modelling colony population growth in the filamentous fungus Aspergillus nidulans

D.R. Gifford, S.E. Schoustra

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Filamentous fungi are ubiquitous in nature and have high societal significance, being both major (food-borne) pathogens and important industrial organisms in the production of antibiotics and enzymes. In addition, fungi are important model organisms for fundamental research, such as studies in genetics and evolutionary biology. However, mechanistic models for population growth that would help understand fungal biology and fundamental processes are almost entirely missing. Here we present such a mechanistic model for the species Aspergillus nidulans as an exemplar of models for other filamentous fungi. The model is based on physiological parameters that influence colony growth, namely mycelial growth rate and sporulation rate, to predict the number of individual nuclei present in a colony through time. Using population size data for colonies of differing ages, we find that our mechanistic model accurately predicts the number of nuclei for two growth environments, and show that fungal population size is most dependent on changes in mycelial growth rate. (c) 2012 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)124-130
JournalJournal of Theoretical Biology
Volume320
DOIs
Publication statusPublished - 2013

Fingerprint

Aspergillus nidulans
Population Growth
Aspergillus
mechanistic models
Fungi
population growth
fungi
population size
Growth
Population Density
Modeling
Biological Sciences
organisms
food pathogens
Population Size
sporulation
Nucleus
Biology
antibiotics
Model

Keywords

  • asexual sporulation
  • solid substrate
  • evolution
  • kinetics
  • microorganisms
  • microbiology
  • adaptation
  • stress
  • size

Cite this

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title = "Modelling colony population growth in the filamentous fungus Aspergillus nidulans",
abstract = "Filamentous fungi are ubiquitous in nature and have high societal significance, being both major (food-borne) pathogens and important industrial organisms in the production of antibiotics and enzymes. In addition, fungi are important model organisms for fundamental research, such as studies in genetics and evolutionary biology. However, mechanistic models for population growth that would help understand fungal biology and fundamental processes are almost entirely missing. Here we present such a mechanistic model for the species Aspergillus nidulans as an exemplar of models for other filamentous fungi. The model is based on physiological parameters that influence colony growth, namely mycelial growth rate and sporulation rate, to predict the number of individual nuclei present in a colony through time. Using population size data for colonies of differing ages, we find that our mechanistic model accurately predicts the number of nuclei for two growth environments, and show that fungal population size is most dependent on changes in mycelial growth rate. (c) 2012 Elsevier Ltd. All rights reserved.",
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Modelling colony population growth in the filamentous fungus Aspergillus nidulans. / Gifford, D.R.; Schoustra, S.E.

In: Journal of Theoretical Biology, Vol. 320, 2013, p. 124-130.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Modelling colony population growth in the filamentous fungus Aspergillus nidulans

AU - Gifford, D.R.

AU - Schoustra, S.E.

N1 - WOS:000315011800013

PY - 2013

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AB - Filamentous fungi are ubiquitous in nature and have high societal significance, being both major (food-borne) pathogens and important industrial organisms in the production of antibiotics and enzymes. In addition, fungi are important model organisms for fundamental research, such as studies in genetics and evolutionary biology. However, mechanistic models for population growth that would help understand fungal biology and fundamental processes are almost entirely missing. Here we present such a mechanistic model for the species Aspergillus nidulans as an exemplar of models for other filamentous fungi. The model is based on physiological parameters that influence colony growth, namely mycelial growth rate and sporulation rate, to predict the number of individual nuclei present in a colony through time. Using population size data for colonies of differing ages, we find that our mechanistic model accurately predicts the number of nuclei for two growth environments, and show that fungal population size is most dependent on changes in mycelial growth rate. (c) 2012 Elsevier Ltd. All rights reserved.

KW - asexual sporulation

KW - solid substrate

KW - evolution

KW - kinetics

KW - microorganisms

KW - microbiology

KW - adaptation

KW - stress

KW - size

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JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

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