Modeling competition between yeast strains

Maarten de Gee*, Hilda Van Mourik, Arjan De Visser, Jaap Molenaar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review


We investigate toxin interference competition between S. cerevisiae colonies grown on a solid medium. In vivo experiments show that the outcome of this competition depends strongly on nutrient availability and cell densities. Here we present a new model for S. cerevisiae colonies, calculating the local height and composition of the colonies. The model simulates yeast colonies that show a good fit to experimental data. Simulations of colonies that start out with a homogeneous mixture of toxin producing and toxin sensitive cells can display remarkable pattern formation, depending on the initial ratio of the strains. Simulations in which the toxin producing and toxin sensitive species start at nearby positions clearly show that toxin production is advantageous.

Original languageEnglish
Title of host publicationAIP Conference Proceedings, Bandung, Indonesia, 4–6 November 2015
PublisherAmerican Institute of Physics
ISBN (Print)9780735413702
Publication statusPublished - 6 Apr 2016
EventSymposium on Biomathematics, SYMOMATH 2015 - Bandung, Indonesia
Duration: 4 Nov 20156 Nov 2015


ConferenceSymposium on Biomathematics, SYMOMATH 2015


Dive into the research topics of 'Modeling competition between yeast strains'. Together they form a unique fingerprint.

Cite this