Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits

N. Carraro, N. Rivard, V. Burrus, Daniela Ceccarelli

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Mobile genetic elements are near ubiquitous DNA segments that revealed a surprising variety of strategies for their propagation among prokaryotes and between eukaryotes. In bacteria, conjugative elements were shown to be key drivers of evolution and adaptation by efficiently disseminating genes involved in pathogenicity, symbiosis, metabolic pathways, and antibiotic resistance. Conjugative plasmids of the incompatibility groups A and C (A/C) are important vehicles for the dissemination of antibiotic resistance and the consequent global emergence and spread of multi-resistant pathogenic bacteria. Beyond their own mobility, A/C plasmids were also shown to drive the mobility of unrelated non-autonomous mobilizable genomic islands, which may also confer further advantageous traits. In this commentary, we summarize the current knowledge on different classes of A/C-dependent mobilizable genomic islands and we discuss other DNA hitchhikers and their implication in bacterial evolution. Furthermore, we glimpse at the complex genetic network linking autonomous and non-autonomous mobile genetic elements, and at the associated flow of genetic information between bacteria.
Original languageEnglish
Pages (from-to)1-6
JournalMobile Genetic Elements
Volume7
Issue number2
DOIs
Publication statusPublished - 2017

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Genomic Islands
Multiple Drug Resistance
Interspersed Repetitive Sequences
Bacteria
Microbial Drug Resistance
Plasmids
Anti-Bacterial Agents
Symbiosis
DNA
Metabolic Networks and Pathways
Eukaryota
Virulence
Genes

Cite this

Carraro, N. ; Rivard, N. ; Burrus, V. ; Ceccarelli, Daniela. / Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits. In: Mobile Genetic Elements. 2017 ; Vol. 7, No. 2. pp. 1-6.
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Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits. / Carraro, N. ; Rivard, N. ; Burrus, V. ; Ceccarelli, Daniela.

In: Mobile Genetic Elements, Vol. 7, No. 2, 2017, p. 1-6.

Research output: Contribution to journalArticleAcademicpeer-review

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