Mining bacterial genomes to reveal secret synergy

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The medical treatment of infectious diseases often requires combination therapies that blend two molecules to enhance drug efficacy. Nature does the same. In a new article, Mrak et al. identify and functionally characterize natural products from Streptomyces rapamycinicus that show synergistic antifungal activity with the well-known immunosuppressant metabolite rapamycin, produced by the same strain. The genomic co-association of the two biosynthetic gene clusters paves the way toward new strategies to discover synergistic pairs of antibiotics through large-scale genome mining.

Original languageEnglish
Pages (from-to)19996-19997
JournalThe Journal of biological chemistry
Volume293
Issue number52
DOIs
Publication statusPublished - 28 Dec 2018

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Bacterial Genomes
Streptomyces
Sirolimus
Immunosuppressive Agents
Multigene Family
Biological Products
Communicable Diseases
Genes
Genome
Anti-Bacterial Agents
Metabolites
Pharmaceutical Preparations
Molecules
Therapeutics

Cite this

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title = "Mining bacterial genomes to reveal secret synergy",
abstract = "The medical treatment of infectious diseases often requires combination therapies that blend two molecules to enhance drug efficacy. Nature does the same. In a new article, Mrak et al. identify and functionally characterize natural products from Streptomyces rapamycinicus that show synergistic antifungal activity with the well-known immunosuppressant metabolite rapamycin, produced by the same strain. The genomic co-association of the two biosynthetic gene clusters paves the way toward new strategies to discover synergistic pairs of antibiotics through large-scale genome mining.",
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Mining bacterial genomes to reveal secret synergy. / Alanjary, Mohammad; Medema, Marnix H.

In: The Journal of biological chemistry, Vol. 293, No. 52, 28.12.2018, p. 19996-19997.

Research output: Contribution to journalArticleAcademicpeer-review

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