Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

Robert M. Bowers*, Nikos C. Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud, T.B.K. Reddy, Frederik Schulz, Jessica Jarett, Adam R. Rivers, Emiley A. Eloe-Fadrosh, Susannah G. Tringe, Natalia N. Ivanova, Alex Copeland, Alicia Clum, Eric D. Becraft, Rex R. Malmstrom, Bruce Birren, Mircea Podar, Peer Bork, George M. WeinstockGeorge M. Garrity, Jeremy A. Dodsworth, Shibu Yooseph, Granger Sutton, Frank O. Glöckner, Jack A. Gilbert, William C. Nelson, Steven J. Hallam, Sean P. Jungbluth, Thijs J.G. Ettema, Scott Tighe, Konstantinos T. Konstantinidis, Wen Tso Liu, Brett J. Baker, Thomas Rattei, Jonathan A. Eisen, Brian Hedlund, Katherine D. McMahon, Noah Fierer, Rob Knight, Rob Finn, Guy Cochrane, Ilene Karsch-Mizrachi, Gene W. Tyson, Christian Rinke, Alla Lapidus, Folker Meyer, Pelin Yilmaz, Donovan H. Parks, A.M. Eren

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

750 Citations (Scopus)


We present two standards developed by the Genomic Standards Consortium (GSC) for reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum Information about Any (x) Sequence (MIxS). The standards are the Minimum Information about a Single Amplified Genome (MISAG) and the Minimum Information about a Metagenome-Assembled Genome (MIMAG), including, but not limited to, assembly quality, and estimates of genome completeness and contamination. These standards can be used in combination with other GSC checklists, including the Minimum Information about a Genome Sequence (MIGS), Minimum Information about a Metagenomic Sequence (MIMS), and Minimum Information about a Marker Gene Sequence (MIMARKS). Community-wide adoption of MISAG and MIMAG will facilitate more robust comparative genomic analyses of bacterial and archaeal diversity.

Original languageEnglish
Pages (from-to)725-731
Number of pages7
JournalNature Biotechnology
Issue number8
Publication statusPublished - 8 Aug 2017
Externally publishedYes


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