Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

H. Bouwmeester; I. Lynch; H.J.P. Marvin; K.A. Dawson; M. Berges; D. Braguer; H.J. Byrne; A. Casey; G. Chambers; M.J.D. Clift; G. Elia; T.F. Fernandes; L.B. fjellsbo; P. Hatto; L. Juillerat; C. Klein; W.G. Kreyling; C. Nickel; M. Riediker; V. Stone

doi:10.3109/17435391003775266

Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

H. Bouwmeester, I. Lynch, H.J.P. Marvin, K.A. Dawson, M. Berges, D. Braguer, H.J. Byrne, A. Casey, G. Chambers, M.J.D. Clift, G. Elia, T.F. Fernandes, L.B. fjellsbo, P. Hatto, L. Juillerat, C. Klein, W.G. Kreyling, C. Nickel, M. Riediker, V. Stone

Research output: Contribution to journal › Article › Academic › peer-review

139 Citations (Scopus)

Abstract

This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix Read More: http://informahealthcare.com/doi/abs/10.3109/17435391003775266

Original language	English
Pages (from-to)	1-11
Journal	Nanotoxicology
Volume	5
Issue number	1
DOIs	https://doi.org/10.3109/17435391003775266
Publication status	Published - 2011

Keywords

environmental risk-assessment
walled carbon nanotubes
in-vitro
safety evaluation
surface-area
ultrafine particles
research strategies
oxidative stress
protein corona
nanoparticles

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10.3109/17435391003775266

Risico's nanotechnologie biobeschikbaarheid en toxicologie contrafinanciering (KB-37-002-001, KB-23-002-005, KB-15-003-010)
Peters, R. (Project Leader)
1/01/11 → 31/12/21
Project: LVVN project
NANOIMPACTNET: European Network on the Health and Environmental Impact of Nanomaterials
1/04/08 → 31/03/12
Project: EU research project

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Bouwmeester, H., Lynch, I., Marvin, H. J. P., Dawson, K. A., Berges, M., Braguer, D., Byrne, H. J., Casey, A., Chambers, G., Clift, M. J. D., Elia, G., Fernandes, T. F., fjellsbo, L. B., Hatto, P., Juillerat, L., Klein, C., Kreyling, W. G., Nickel, C., Riediker, M., & Stone, V. (2011). Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology, 5(1), 1-11. https://doi.org/10.3109/17435391003775266

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title = "Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices",

abstract = "This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix Read More: http://informahealthcare.com/doi/abs/10.3109/17435391003775266",

keywords = "environmental risk-assessment, walled carbon nanotubes, in-vitro, safety evaluation, surface-area, ultrafine particles, research strategies, oxidative stress, protein corona, nanoparticles",

author = "H. Bouwmeester and I. Lynch and H.J.P. Marvin and K.A. Dawson and M. Berges and D. Braguer and H.J. Byrne and A. Casey and G. Chambers and M.J.D. Clift and G. Elia and T.F. Fernandes and L.B. fjellsbo and P. Hatto and L. Juillerat and C. Klein and W.G. Kreyling and C. Nickel and M. Riediker and V. Stone",

year = "2011",

doi = "10.3109/17435391003775266",

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Bouwmeester, H, Lynch, I, Marvin, HJP, Dawson, KA, Berges, M, Braguer, D, Byrne, HJ, Casey, A, Chambers, G, Clift, MJD, Elia, G, Fernandes, TF, fjellsbo, LB, Hatto, P, Juillerat, L, Klein, C, Kreyling, WG, Nickel, C, Riediker, M & Stone, V 2011, 'Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices', Nanotoxicology, vol. 5, no. 1, pp. 1-11. https://doi.org/10.3109/17435391003775266

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T1 - Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

AU - Bouwmeester, H.

AU - Lynch, I.

AU - Marvin, H.J.P.

AU - Dawson, K.A.

AU - Berges, M.

AU - Braguer, D.

AU - Byrne, H.J.

AU - Casey, A.

AU - Chambers, G.

AU - Clift, M.J.D.

AU - Elia, G.

AU - Fernandes, T.F.

AU - fjellsbo, L.B.

AU - Hatto, P.

AU - Juillerat, L.

AU - Klein, C.

AU - Kreyling, W.G.

AU - Nickel, C.

AU - Riediker, M.

AU - Stone, V.

PY - 2011

Y1 - 2011

N2 - This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix Read More: http://informahealthcare.com/doi/abs/10.3109/17435391003775266

AB - This paper presents the outcomes from a workshop of the European Network on the Health and Environmental Impact of Nanomaterials (NanoImpactNet). During the workshop, 45 experts in the field of safety assessment of engineered nanomaterials addressed the need to systematically study sets of engineered nanomaterials with specific metrics to generate a data set which would allow the establishment of dose-response relations. The group concluded that international cooperation and worldwide standardization of terminology, reference materials and protocols are needed to make progress in establishing lists of essential metrics. High quality data necessitates the development of harmonized study approaches and adequate reporting of data. Priority metrics can only be based on well-characterized dose-response relations derived from the systematic study of the bio-kinetics and bio-interactions of nanomaterials at both organism and (sub)-cellular levels. In addition, increased effort is needed to develop and validate analytical methods to determine these metrics in a complex matrix Read More: http://informahealthcare.com/doi/abs/10.3109/17435391003775266

KW - environmental risk-assessment

KW - walled carbon nanotubes

KW - in-vitro

KW - safety evaluation

KW - surface-area

KW - ultrafine particles

KW - research strategies

KW - oxidative stress

KW - protein corona

KW - nanoparticles

U2 - 10.3109/17435391003775266

DO - 10.3109/17435391003775266

M3 - Article

SN - 1743-5390

VL - 5

SP - 1

EP - 11

JO - Nanotoxicology

JF - Nanotoxicology

IS - 1

ER -

Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices

Abstract

Keywords

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Projects

Risico's nanotechnologie biobeschikbaarheid en toxicologie contrafinanciering (KB-37-002-001, KB-23-002-005, KB-15-003-010)

NANOIMPACTNET: European Network on the Health and Environmental Impact of Nanomaterials

Cite this