Microcapsules with a pH responsive polymer: Influence of the encapsulated oil on the capsule morphology

N.A. Wagdare, A.T.M. Marcelis, R.M. Boom, C.J.M. van Rijn

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Microcapsules were prepared by microsieve membrane cross flow emulsification of Eudragit FS 30D/dichloromethane/edible oil mixtures in water, and subsequent phase separation induced by extraction of the dichloromethane through an aqueous phase. For long-chain triglycerides and jojoba oil, core–shell particles were obtained with the oil as core, surrounded by a shell of Eudragit. Medium chain triglyceride (MCT oil) was encapsulated as relatively small droplets in the Eudragit matrix. The morphology of the formed capsules was investigated with optical and SEM microscopy. Extraction of the oil from the core–shell capsules with hexane resulted in hollow Eudragit capsules with porous shells. It was shown that the differences are related to the compatibility of the oils with the shell-forming Eudragit. An oil with poor compatibility yields microcapsules with a dense Eudragit shell on a single oil droplet as the core; oils having better compatibility yield porous Eudragit spheres with several oil droplets trapped inside
Original languageEnglish
Pages (from-to)175-180
JournalColloids and Surfaces. B: Biointerfaces
Volume88
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • hollow polylactide microcapsules
  • premix membrane emulsification
  • internal phase-separation
  • mechanical-properties
  • shell microcapsules
  • emulsion droplets
  • lipophilic drugs
  • contrast agents
  • release
  • delivery

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