Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins

Nick C. Snelders, Hanna Rovenich, Gabriella C. Petti, Mercedes Rocafort, Grardy C.M. van den Berg, Julia A. Vorholt, Jeroen R. Mesters, Michael F. Seidl, Reindert Nijland, Bart P.H.J. Thomma*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

During colonization of their hosts, pathogens secrete effector proteins to promote disease development through various mechanisms. Increasing evidence shows that the host microbiome plays a crucial role in health, and that hosts actively shape their microbiomes to suppress disease. We proposed that pathogens evolved to manipulate host microbiomes to their advantage in turn. Here, we show that the previously identified virulence effector VdAve1, secreted by the fungal plant pathogen Verticillium dahliae, displays antimicrobial activity and facilitates colonization of tomato and cotton through the manipulation of their microbiomes by suppressing antagonistic bacteria. Moreover, we show that VdAve1, and also the newly identified antimicrobial effector VdAMP2, are exploited for microbiome manipulation in the soil environment, where the fungus resides in absence of a host. In conclusion, we demonstrate that a fungal plant pathogen uses effector proteins to modulate microbiome compositions inside and outside the host, and propose that pathogen effector catalogues represent an untapped resource for new antibiotics.

Original languageEnglish
Pages (from-to)1365-1374
JournalNature Plants
Volume6
DOIs
Publication statusPublished - 2 Nov 2020

Fingerprint Dive into the research topics of 'Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins'. Together they form a unique fingerprint.

Cite this