Microbial production of bulk chemicals: development of anaerobic processes

R.A. Weusthuis, I. Lamot, J. van der Oost, J.P.M. Sanders

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)

Abstract

nnovative fermentation processes are necessary for the cost-effective production of bulk chemicals from renewable resources. Current microbial processes are either anaerobic processes, with high yield and productivity, or less-efficient aerobic processes. Oxygen utilization plays an important role in energy generation and redox metabolism that is necessary for product formation. The aerobic productivity, however, is relatively low because of rate-limiting volumetric oxygen transfer; whereas the product yield in the presence of oxygen is generally low because part of the substrate is completely oxidized to CO2. Hence, new microbial conversion processes for the production of bulk chemicals should be anaerobic. In this opinion article, we describe different scenarios for the development of highly efficient microbial conversion processes for the anaerobic production of bulk chemicals
Original languageEnglish
Pages (from-to)153-158
JournalTrends in Biotechnology
Volume29
Issue number4
DOIs
Publication statusPublished - 2011

Keywords

  • escherichia-coli
  • saccharomyces-cerevisiae
  • corynebacterium-glutamicum
  • glycerol production
  • acid production
  • succinic acid
  • fermentation
  • transhydrogenase
  • regeneration
  • metabolism

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