Microbial hosts engineered for increased tolerance to temperature shifts

Linde Francisca Cornelia Kampers (Inventor), Joanna Maria Volkers (Inventor), Petrus Johannes Schaap (Inventor), Vitor Alexandre Pires Martins Dos Santos (Inventor)

Research output: PatentOther research output

Abstract

The present invention relates to microbial host cells that have been engineered for increased tolerance to temperature shifts, for increased performance at temperatures different from the microorganism's optimal temperature and/or for changing at least one of the microorganism's cardinal temperatures by replacing an endogenous NAD+ biosynthesis gene by a heterologous gene encoding a corresponding enzyme with another temperature profile and/or from a microorganism with a different optimum growth temperature.The invention further relates to processes wherein the engineered microbial host cells are used for producing a fermentation product,and to the use nucleotide sequences encoding NAD+ biosynthesis gene for changing at least one of a microorganism's cardinal temperatures and/or for improving a microorganism's tolerance to temperature shifts.

Original languageEnglish
Patent numberWO2020094828
Priority date9/11/18
Publication statusPublished - 14 May 2020

Fingerprint Dive into the research topics of 'Microbial hosts engineered for increased tolerance to temperature shifts'. Together they form a unique fingerprint.

  • Cite this