Abstract
The present invention relates to a method for the production of collagen-like compounds containing hydroxylated proline residues. Of specific interest is the production of recombinant collagen-like compounds in which hydroxylation of proline residues is achieved by a prolyl hydroxylase from a fungus, preferably a yeast, in particular Hansenula polymorpha. Also the invention concerns a method for controlling the hydroxylation of proline residues by such a prolyl hydroxylase characterised by the addition of collagen-like oligopeptides, such as gelatine hydrolysate, in particular gelatone or peptone.
| Original language | English |
|---|---|
| Patent number | WO0204615 |
| Priority date | 11/07/00 |
| Publication status | Published - 17 Jan 2002 |
Keywords
- Collagens, preparation
- Proteins
- Hydroxylation
- Microorganism
- Glyoproteins
- Gelatins, processes
- Cryptococcus curvatus
- Fungi
- Kluyveromyces lactis
- Komagataella pastoris
- Pichia angusta
- Saccharomyces cerevisiae
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