Methanol-based chain elongation of acetate to i/n- butyrate by enriched microbiomes

Research output: Chapter in Book/Report/Conference proceedingAbstract


Highlights: An enriched methanol-based chain elongation microbiome was capable of producing isobutyrate and n-butyrate at a concentration ratio that approached thermodynamic equilibrium of isomerization.
The usage of isobutyrate as electron acceptor within an enriched ethanol-based chain elongation microbiome led to isocaproate formation. Similarly isovalerate addition led to isoheptanoate formation, however at a much lower selectivity.
Carboxylates larger than acetate can be reduced to their corresponding alcohols with electrons derived from ethanol oxidation towards acetate. To drive this process the reactant to product ratios of the coupled reaction need to be sufficiently high.
Original languageEnglish
Title of host publication1st International Chain Elongation Conference: Connecting Communities
Subtitle of host publicationBook of Abstracts
EditorsD. Strik, K. de Leeuw, C. Contrera Davila, S. de Smit
PublisherWageningen University & Research
Publication statusPublished - 2 Nov 2020
Event1st International Chain Elongation Conference 2020: Connecting Communities - Online
Duration: 26 Oct 202027 Oct 2020


Conference1st International Chain Elongation Conference 2020
Abbreviated titleICEC 2020


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