Metabolomic engineering for the microbial production of cartenoids and related products with a focus on the rare C50 carotenoids

S.A.E. Heider, P. Peters-Wendisch, V.F. Wendisch, M.J. Beekwilder

Research output: Contribution to journalReview articleAcademicpeer-review

40 Citations (Scopus)

Abstract

Carotenoids, a subfamily of terpenoids, are yellowtored-colored pigments synthesized by plants, fungi, algae, and bacteria. They are ubiquitous in nature and take over crucial roles in many biological processes as for example photosynthesis, vision, and the quenching of free radicals and singlet oxygen. Due to their color and their potential beneficial effects on human health, carotenoids receive increasing attention. Carotenoids can be classified due to the length of their carbon backbone. Most carotenoids have a C40 backbone, but also C30 and C50 carotenoids are known. All carotenoids are derived fromisopentenyl pyrophosphate (IPP) as a common precursor. Pathways leading to IPP as well as metabolic engineering of IPP synthesis and C40 carotenoid production have been reviewed expertly elsewhere. Since C50 carotenoids are synthesized from the C40 carotenoid lycopene, we will summarize common strategies for optimizing lycopene production and we will focus our review on the characteristics, biosynthesis, glycosylation, and overproduction of C50 carotenoids.
LanguageEnglish
Pages4355-4368
JournalApplied Microbiology and Biotechnology
Volume98
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Metabolomics
Carotenoids
Metabolic Engineering
Biological Phenomena
Singlet Oxygen
Terpenes
Photosynthesis
Glycosylation
Free Radicals
Fungi
Carbon
Color
Bacteria

Keywords

  • alga haematococcus-pluvialis
  • blue-light photoreception
  • escherichia-coli
  • bacterial carotenoids
  • biosynthetic-pathway
  • bacillus-subtilis
  • astaxanthin biosynthesis
  • functional-analysis
  • beta-carotene
  • corynebacterium-glutamicum

Cite this

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abstract = "Carotenoids, a subfamily of terpenoids, are yellowtored-colored pigments synthesized by plants, fungi, algae, and bacteria. They are ubiquitous in nature and take over crucial roles in many biological processes as for example photosynthesis, vision, and the quenching of free radicals and singlet oxygen. Due to their color and their potential beneficial effects on human health, carotenoids receive increasing attention. Carotenoids can be classified due to the length of their carbon backbone. Most carotenoids have a C40 backbone, but also C30 and C50 carotenoids are known. All carotenoids are derived fromisopentenyl pyrophosphate (IPP) as a common precursor. Pathways leading to IPP as well as metabolic engineering of IPP synthesis and C40 carotenoid production have been reviewed expertly elsewhere. Since C50 carotenoids are synthesized from the C40 carotenoid lycopene, we will summarize common strategies for optimizing lycopene production and we will focus our review on the characteristics, biosynthesis, glycosylation, and overproduction of C50 carotenoids.",
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Metabolomic engineering for the microbial production of cartenoids and related products with a focus on the rare C50 carotenoids. / Heider, S.A.E.; Peters-Wendisch, P.; Wendisch, V.F.; Beekwilder, M.J.

In: Applied Microbiology and Biotechnology, Vol. 98, No. 10, 2014, p. 4355-4368.

Research output: Contribution to journalReview articleAcademicpeer-review

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AU - Heider, S.A.E.

AU - Peters-Wendisch, P.

AU - Wendisch, V.F.

AU - Beekwilder, M.J.

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