Metabolomic Changes after Coffee Consumption: New Paths on the Block

Claudia Favari; Laura Righetti; Michele Tassotti; Lee Andrew Gethings; Daniela Martini; Alice Rosi; Monica Antonini; Josep Rubert; Claudine Manach; Alessandra Dei Cas; Riccardo Bonadonna; Furio Brighenti; Chiara Dall'Asta; Pedro Mena; Daniele Del Rio

doi:10.1002/mnfr.202000875

Metabolomic Changes after Coffee Consumption: New Paths on the Block

Claudia Favari, Laura Righetti, Michele Tassotti, Lee Andrew Gethings, Daniela Martini, Alice Rosi, Monica Antonini, Josep Rubert, Claudine Manach, Alessandra Dei Cas, Riccardo Bonadonna, Furio Brighenti, Chiara Dall'Asta, Pedro Mena^*, Daniele Del Rio

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Scope: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results: A three-arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion: This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.

Original language	English
Article number	2000875
Journal	Molecular Nutrition and Food Research
Volume	65
Issue number	3
DOIs	https://doi.org/10.1002/mnfr.202000875
Publication status	Published - Feb 2021
Externally published	Yes

Keywords

biomarker
cocoa
coffee
metabolomics
xenobiotics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/mnfr.202000875

Cite this

Favari, C., Righetti, L., Tassotti, M., Gethings, L. A., Martini, D., Rosi, A., Antonini, M., Rubert, J., Manach, C., Dei Cas, A., Bonadonna, R., Brighenti, F., Dall'Asta, C., Mena, P., & Del Rio, D. (2021). Metabolomic Changes after Coffee Consumption: New Paths on the Block. Molecular Nutrition and Food Research, 65(3), Article 2000875. https://doi.org/10.1002/mnfr.202000875

@article{385db64a63d640ec8d7d9089b326b409,

title = "Metabolomic Changes after Coffee Consumption: New Paths on the Block",

abstract = "Scope: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results: A three-arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion: This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.",

keywords = "biomarker, cocoa, coffee, metabolomics, xenobiotics",

author = "Claudia Favari and Laura Righetti and Michele Tassotti and Gethings, {Lee Andrew} and Daniela Martini and Alice Rosi and Monica Antonini and Josep Rubert and Claudine Manach and {Dei Cas}, Alessandra and Riccardo Bonadonna and Furio Brighenti and Chiara Dall'Asta and Pedro Mena and {Del Rio}, Daniele",

year = "2021",

month = feb,

doi = "10.1002/mnfr.202000875",

language = "English",

volume = "65",

journal = "Molecular Nutrition and Food Research",

issn = "1613-4125",

publisher = "VCH",

number = "3",

}

TY - JOUR

T1 - Metabolomic Changes after Coffee Consumption: New Paths on the Block

AU - Favari, Claudia

AU - Righetti, Laura

AU - Tassotti, Michele

AU - Gethings, Lee Andrew

AU - Martini, Daniela

AU - Rosi, Alice

AU - Antonini, Monica

AU - Rubert, Josep

AU - Manach, Claudine

AU - Dei Cas, Alessandra

AU - Bonadonna, Riccardo

AU - Brighenti, Furio

AU - Dall'Asta, Chiara

AU - Mena, Pedro

AU - Del Rio, Daniele

PY - 2021/2

Y1 - 2021/2

N2 - Scope: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results: A three-arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion: This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.

AB - Scope: Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results: A three-arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion: This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.

KW - biomarker

KW - cocoa

KW - coffee

KW - metabolomics

KW - xenobiotics

U2 - 10.1002/mnfr.202000875

DO - 10.1002/mnfr.202000875

M3 - Article

C2 - 33300301

AN - SCOPUS:85098169554

SN - 1613-4125

VL - 65

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

IS - 3

M1 - 2000875

ER -

Metabolomic Changes after Coffee Consumption: New Paths on the Block

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this