Metabolome-guided genome mining of RiPP natural products

Mitja M. Zdouc; Justin J.J. van der Hooft; Marnix H. Medema

doi:10.1016/j.tips.2023.06.004

Metabolome-guided genome mining of RiPP natural products

Mitja M. Zdouc^*, Justin J.J. van der Hooft^*, Marnix H. Medema^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) from microorganisms show high chemical diversity and exhibit potent biological properties.
The computational detection of novel classes of RiPPs is hampered by their short length and the lack of universally conserved genes.
The high false-positive rate of class-independent computational detection approaches can be addressed by validation via mass spectrometry-based metabolomics.

Original language	English
Pages (from-to)	532-541
Number of pages	10
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/j.tips.2023.06.004
Publication status	Published - Aug 2023

Keywords

drug discovery
genomics
metabolomics
natural products
ribosomally synthesized and post-translationally modified peptides
RiPPs

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10.1016/j.tips.2023.06.004

https://edepot.wur.nl/636409Licence: Taverne

MARBLES: Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
1/05/21 → 30/04/26
Project: EU research project

Cite this

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title = "Metabolome-guided genome mining of RiPP natural products",

abstract = "Ribosomally synthesized and post-translationally modified peptides (RiPPs) from microorganisms show high chemical diversity and exhibit potent biological properties.The computational detection of novel classes of RiPPs is hampered by their short length and the lack of universally conserved genes.The high false-positive rate of class-independent computational detection approaches can be addressed by validation via mass spectrometry-based metabolomics.",

keywords = "drug discovery, genomics, metabolomics, natural products, ribosomally synthesized and post-translationally modified peptides, RiPPs",

author = "Zdouc, {Mitja M.} and {van der Hooft}, {Justin J.J.} and Medema, {Marnix H.}",

year = "2023",

month = aug,

doi = "10.1016/j.tips.2023.06.004",

language = "English",

volume = "44",

pages = "532--541",

journal = "Trends in Pharmacological Sciences",

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T1 - Metabolome-guided genome mining of RiPP natural products

AU - Zdouc, Mitja M.

AU - van der Hooft, Justin J.J.

AU - Medema, Marnix H.

PY - 2023/8

Y1 - 2023/8

N2 - Ribosomally synthesized and post-translationally modified peptides (RiPPs) from microorganisms show high chemical diversity and exhibit potent biological properties.The computational detection of novel classes of RiPPs is hampered by their short length and the lack of universally conserved genes.The high false-positive rate of class-independent computational detection approaches can be addressed by validation via mass spectrometry-based metabolomics.

AB - Ribosomally synthesized and post-translationally modified peptides (RiPPs) from microorganisms show high chemical diversity and exhibit potent biological properties.The computational detection of novel classes of RiPPs is hampered by their short length and the lack of universally conserved genes.The high false-positive rate of class-independent computational detection approaches can be addressed by validation via mass spectrometry-based metabolomics.

KW - drug discovery

KW - genomics

KW - metabolomics

KW - natural products

KW - ribosomally synthesized and post-translationally modified peptides

KW - RiPPs

U2 - 10.1016/j.tips.2023.06.004

DO - 10.1016/j.tips.2023.06.004

M3 - Article

C2 - 37391295

AN - SCOPUS:85163505568

SN - 0165-6147

VL - 44

SP - 532

EP - 541

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 8

ER -

Metabolome-guided genome mining of RiPP natural products

Abstract

Keywords

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Projects

MARBLES: Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases

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