Metabolic responses to mild cold acclimation in type 2 diabetes patients

Carlijn M.E. Remie; Michiel P.B. Moonen; Kay H.M. Roumans; Emmani B.M. Nascimento; Anne Gemmink; Bas Havekes; Gert Schaart; Esther Kornips; Peter J. Joris; Vera B. Schrauwen-Hinderling; Joris Hoeks; Sander Kersten; Matthijs K.C. Hesselink; Esther Phielix; Wouter D. van Marken Lichtenbelt; Patrick Schrauwen

doi:10.1038/s41467-021-21813-0

Metabolic responses to mild cold acclimation in type 2 diabetes patients

Carlijn M.E. Remie, Michiel P.B. Moonen, Kay H.M. Roumans, Emmani B.M. Nascimento, Anne Gemmink, Bas Havekes, Gert Schaart, Esther Kornips, Peter J. Joris, Vera B. Schrauwen-Hinderling, Joris Hoeks, Sander Kersten, Matthijs K.C. Hesselink, Esther Phielix, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.

Original language	English
Article number	1516
Journal	Nature Communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-021-21813-0
Publication status	Published - 9 Mar 2021

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Remie, C. M. E., Moonen, M. P. B., Roumans, K. H. M., Nascimento, E. B. M., Gemmink, A., Havekes, B., Schaart, G., Kornips, E., Joris, P. J., Schrauwen-Hinderling, V. B., Hoeks, J., Kersten, S., Hesselink, M. K. C., Phielix, E., van Marken Lichtenbelt, W. D., & Schrauwen, P. (2021). Metabolic responses to mild cold acclimation in type 2 diabetes patients. Nature Communications, 12(1), Article 1516. https://doi.org/10.1038/s41467-021-21813-0

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abstract = "Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.",

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Remie, CME, Moonen, MPB, Roumans, KHM, Nascimento, EBM, Gemmink, A, Havekes, B, Schaart, G, Kornips, E, Joris, PJ, Schrauwen-Hinderling, VB, Hoeks, J, Kersten, S, Hesselink, MKC, Phielix, E, van Marken Lichtenbelt, WD & Schrauwen, P 2021, 'Metabolic responses to mild cold acclimation in type 2 diabetes patients', Nature Communications, vol. 12, no. 1, 1516. https://doi.org/10.1038/s41467-021-21813-0

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AU - Remie, Carlijn M.E.

AU - Moonen, Michiel P.B.

AU - Roumans, Kay H.M.

AU - Nascimento, Emmani B.M.

AU - Gemmink, Anne

AU - Havekes, Bas

AU - Schaart, Gert

AU - Kornips, Esther

AU - Joris, Peter J.

AU - Schrauwen-Hinderling, Vera B.

AU - Hoeks, Joris

AU - Kersten, Sander

AU - Hesselink, Matthijs K.C.

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AB - Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL4469/NTR5711) in nine patients with type 2 diabetes that ten days of mild cold acclimation (16–17 °C) in which observable, overt shivering was prevented, does not result in improved insulin sensitivity, postprandial glucose and lipid metabolism or intrahepatic lipid content and only results in mild effects on overnight fasted fat oxidation, postprandial energy expenditure and aortic augmentation index. The lack of marked metabolic effects in this study is associated with a lack of self-reported shivering and a lack of upregulation of gene expression of muscle activation or muscle contraction pathways in skeletal muscle and suggests that some form of muscle contraction is needed for beneficial effects of mild cold acclimation.

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Metabolic responses to mild cold acclimation in type 2 diabetes patients

Abstract

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