Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

Rosalia Ferracane, Giulia Graziani*, Monica Gallo, Vincenzo Fogliano, Alberto Ritieni

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)


In this work the bioactive metabolic profile, the antioxidant activity and total phenolic content of burdock (Arctium lappa) seeds, leaves and roots were obtained. TEAC values and total phenolic content for hydro-alcoholic extracts of burdock ranged from 67.39 to 1.63 μmol Trolox equivalent/100 g dry weight (DW), and from 2.87 to 45 g of gallic acid equivalent/100 g DW, respectively. Phytochemical compounds were analyzed by liquid chromatography coupled to electrospray tandem mass spectrometry (LC/MS/MS) in negative mode. The main compounds of burdock extracts were caffeoylquinic acid derivatives, lignans (mainly arctiin) and various flavonoids. The occurrence of some phenolic acids (caffeic acid, chlorogenic acid and cynarin) in burdock seeds; arctiin, luteolin and quercetin rhamnoside in burdock roots; phenolic acids, quercetin, quercitrin and luteolin in burdock leaves was reported for the first time.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Issue number2
Publication statusPublished - 20 Jan 2010
Externally publishedYes


  • Antioxidant activity
  • Arctium lappa
  • Caffeoylquinic acid
  • Lignan
  • Tandem mass spectrometry

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