TY - JOUR
T1 - Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
AU - Van Beek, Adriaan A.
AU - Van den Bossche, Jan
AU - Mastroberardino, Pier G.
AU - De Winther, Menno P.J.
AU - Leenen, Pieter J.M.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or ‘inflammaging’. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.
AB - Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or ‘inflammaging’. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.
KW - aging
KW - cell metabolism
KW - epigenetics
KW - inflammation
KW - macrophages
U2 - 10.1016/j.it.2018.12.007
DO - 10.1016/j.it.2018.12.007
M3 - Article
SN - 1471-4906
VL - 40
SP - 113
EP - 127
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -