Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults

A. Jennings, A.M. Berendsen, C.P.G.M. de Groot, E.J.M. Feskens, A. Brzozowska, Ewa Sicinska, Barbara Pietruszka, N. Meunier, Elodie Caumon, Corinne Malpuech-Brugère, Aurelia Santoro, Rita Ostan, Claudio Franceschi, Rachel Gillings, C.M. O'Neill, Susan J. Fairweather-Tait, Anne-Marie Minihane, Aedin Cassidy

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Abstract

We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P=0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.
LanguageEnglish
Pages578-586
JournalHypertension
Volume73
Issue number3
Early online date14 Jan 2019
DOIs
Publication statusPublished - Mar 2019

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Mediterranean Diet
Vascular Stiffness
Blood Pressure
Pulse Wave Analysis
Healthy Volunteers
Potassium
Randomized Controlled Trials
Sodium
Diet
Food
Control Groups
Health

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Jennings, A. ; Berendsen, A.M. ; de Groot, C.P.G.M. ; Feskens, E.J.M. ; Brzozowska, A. ; Sicinska, Ewa ; Pietruszka, Barbara ; Meunier, N. ; Caumon, Elodie ; Malpuech-Brugère, Corinne ; Santoro, Aurelia ; Ostan, Rita ; Franceschi, Claudio ; Gillings, Rachel ; O'Neill, C.M. ; Fairweather-Tait, Susan J. ; Minihane, Anne-Marie ; Cassidy, Aedin. / Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults. In: Hypertension. 2019 ; Vol. 73, No. 3. pp. 578-586.
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abstract = "We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2{\%}), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95{\%} CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95{\%} CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95{\%} CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95{\%} CI, 0.7–16.9; P=0.03) and in male participants (52{\%}) a reduction in pulse pressure (−6.1 mm Hg; 95{\%} CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95{\%} CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.",
author = "A. Jennings and A.M. Berendsen and {de Groot}, C.P.G.M. and E.J.M. Feskens and A. Brzozowska and Ewa Sicinska and Barbara Pietruszka and N. Meunier and Elodie Caumon and Corinne Malpuech-Brug{\`e}re and Aurelia Santoro and Rita Ostan and Claudio Franceschi and Rachel Gillings and C.M. O'Neill and Fairweather-Tait, {Susan J.} and Anne-Marie Minihane and Aedin Cassidy",
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pages = "578--586",
journal = "Hypertension",
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Jennings, A, Berendsen, AM, de Groot, CPGM, Feskens, EJM, Brzozowska, A, Sicinska, E, Pietruszka, B, Meunier, N, Caumon, E, Malpuech-Brugère, C, Santoro, A, Ostan, R, Franceschi, C, Gillings, R, O'Neill, CM, Fairweather-Tait, SJ, Minihane, A-M & Cassidy, A 2019, 'Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults', Hypertension, vol. 73, no. 3, pp. 578-586. https://doi.org/10.1161/HYPERTENSIONAHA.118.12259

Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults. / Jennings, A.; Berendsen, A.M.; de Groot, C.P.G.M.; Feskens, E.J.M.; Brzozowska, A.; Sicinska, Ewa; Pietruszka, Barbara; Meunier, N.; Caumon, Elodie; Malpuech-Brugère, Corinne; Santoro, Aurelia; Ostan, Rita; Franceschi, Claudio; Gillings, Rachel; O'Neill, C.M.; Fairweather-Tait, Susan J.; Minihane, Anne-Marie; Cassidy, Aedin.

In: Hypertension, Vol. 73, No. 3, 03.2019, p. 578-586.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults

AU - Jennings, A.

AU - Berendsen, A.M.

AU - de Groot, C.P.G.M.

AU - Feskens, E.J.M.

AU - Brzozowska, A.

AU - Sicinska, Ewa

AU - Pietruszka, Barbara

AU - Meunier, N.

AU - Caumon, Elodie

AU - Malpuech-Brugère, Corinne

AU - Santoro, Aurelia

AU - Ostan, Rita

AU - Franceschi, Claudio

AU - Gillings, Rachel

AU - O'Neill, C.M.

AU - Fairweather-Tait, Susan J.

AU - Minihane, Anne-Marie

AU - Cassidy, Aedin

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N2 - We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P=0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.

AB - We aimed to determine the effect of a Mediterranean-style diet, tailored to meet dietary recommendations for older adults, on blood pressure and arterial stiffness. In 12 months, randomized controlled trial (NU-AGE [New Dietary Strategies Addressing the Specific Needs of Elderly Population for Healthy Aging in Europe]), blood pressure was measured in 1294 healthy participants, aged 65 to 79 years, recruited from 5 European centers, and arterial stiffness in a subset of 225 participants. The intervention group received individually tailored standardized dietary advice and commercially available foods to increase adherence to a Mediterranean diet. The control group continued on their habitual diet and was provided with current national dietary guidance. In the 1142 participants who completed the trial (88.2%), after 1 year the intervention resulted in a significant reduction in systolic blood pressure (−5.5 mm Hg; 95% CI, −10.7 to −0.4; P=0.03), which was evident in males (−9.2 mm Hg, P=0.02) but not females (−3.1 mm Hg, P=0.37). The −1.7 mm Hg (95% CI, −4.3 to 0.9) decrease in diastolic pressure after intervention did not reach statistical significance. In a subset (n=225), augmentation index, a measure of arterial stiffness, was improved following intervention (−12.4; 95% CI, −24.4 to −0.5; P=0.04) with no change in pulse wave velocity. The intervention also resulted in an increase in 24-hour urinary potassium (8.8 mmol/L; 95% CI, 0.7–16.9; P=0.03) and in male participants (52%) a reduction in pulse pressure (−6.1 mm Hg; 95% CI, −12.0 to −0.2; P=0.04) and 24-hour urinary sodium (−27.1 mmol/L; 95% CI, −53.3 to −1.0; P=0.04). In conclusion, a Mediterranean-style diet is effective in improving cardiovascular health with clinically relevant reductions in blood pressure and arterial stiffness.

U2 - 10.1161/HYPERTENSIONAHA.118.12259

DO - 10.1161/HYPERTENSIONAHA.118.12259

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