Mechanisms of gene regulation by fatty acids

A. Georgiadi, A.H. Kersten

Research output: Contribution to journalArticleAcademicpeer-review

159 Citations (Scopus)

Abstract

Consumption of specific dietary fatty acids has been shown to influence risk and progression of several chronic diseases, such as cardiovascular disease, obesity, cancer, and arthritis. In recent years, insights into the mechanisms underlying the biological effects of fatty acids have improved considerably and have provided the foundation for the emerging concept of fatty acid sensing, which can be interpreted as the property of fatty acids to influence biological processes by serving as signaling molecules. An important mechanism of fatty acid sensing is via stimulation or inhibition of DNA transcription. Here, we focus on fatty acid sensing via regulation of gene transcription and address the role of peroxisome proliferator–activated receptors, sterol regulatory element binding protein 1, Toll-like receptor 4, G protein–coupled receptors, and other putative mediators.
Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalAdvances in Nutrition
Volume3
DOIs
Publication statusPublished - 2012

Keywords

  • activated-receptor-alpha
  • element-binding protein-1
  • retinoid-x-receptor
  • toll-like receptor-4
  • ppar-alpha
  • nuclear receptor
  • coupled-receptor
  • ligand-binding
  • molecular recognition
  • docosahexaenoic acid

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