Mechanism of resistance in Penicillium italicum to fungicides which inhibit sterol 14alpha-demethylation

Biochemistry, Genetics and Molecular Biology

• Demethylation 100%
• Sterol 100%
• Cytochrome P450 50%
• Isozyme 45%
• Wild Type 40%
• Ergosterol 40%
• Lanosterol 14 Alpha-Demethylase 27%
• Anabolism 22%
• Enzyme 18%
• IC50 13%
• Extract 13%
• Metabolic Pathway 9%
• Infectious Agent 9%
• Lipid 4%
• Cell Membrane 4%
• Binding Affinity 4%
• Isolation Procedure 4%
• Cross Resistance 4%
• Sterol Synthesis 4%
• Membrane Potential 4%

Chemistry

• Demethylation 100%
• Fungicide 100%
• Sterol 100%
• Cytochrome P450 45%
• Toxic 22%
• IC50 13%
• Itraconazole 13%
• Fenarimol 13%
• Carbon Monoxide 13%
• Ketoconazole 13%
• Phase Composition 9%
• Fungitoxic 9%
• Kd 4%
• Mevalonate 4%
• Heterocyclic Compound 4%
• Spectrophotometry 4%
• Nitrogen Atom 4%
• Propiconazole 4%
• Penconazole 4%
• Reduced Cytochrome P450 4%
• Miconazole 4%
• Iron Atom 4%
• Heme 4%
• Membrane Potential 4%
• Pyrrole 4%