Maturation of the immune response

S.E.C. van Altena, B. Meijer, H.F.J. Savelkoul

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1ß, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...
Original languageEnglish
Title of host publicationEncyclopedia of Immunotoxicology
EditorsH.W. Vohr
PublisherSpringer
Pages1-11
ISBN (Print)9783642277863
DOIs
Publication statusPublished - 2014

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Pattern Recognition Receptors
Ligation
Flagellin
Peptidoglycan
Toll-Like Receptors
Adaptive Immunity
Interleukin-8
Interleukin-1
Phagocytosis
Natural Killer Cells
Dendritic Cells
Lipopolysaccharides
Immune System
Interleukin-6
B-Lymphocytes
Epithelial Cells
Macrophages
Cell Membrane
Cytokines
Ligands

Cite this

van Altena, S. E. C., Meijer, B., & Savelkoul, H. F. J. (2014). Maturation of the immune response. In H. W. Vohr (Ed.), Encyclopedia of Immunotoxicology (pp. 1-11). Springer. https://doi.org/10.1007/978-3-642-27786-3_957-2
van Altena, S.E.C. ; Meijer, B. ; Savelkoul, H.F.J. / Maturation of the immune response. Encyclopedia of Immunotoxicology. editor / H.W. Vohr. Springer, 2014. pp. 1-11
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van Altena, SEC, Meijer, B & Savelkoul, HFJ 2014, Maturation of the immune response. in HW Vohr (ed.), Encyclopedia of Immunotoxicology. Springer, pp. 1-11. https://doi.org/10.1007/978-3-642-27786-3_957-2

Maturation of the immune response. / van Altena, S.E.C.; Meijer, B.; Savelkoul, H.F.J.

Encyclopedia of Immunotoxicology. ed. / H.W. Vohr. Springer, 2014. p. 1-11.

Research output: Chapter in Book/Report/Conference proceedingChapter

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van Altena SEC, Meijer B, Savelkoul HFJ. Maturation of the immune response. In Vohr HW, editor, Encyclopedia of Immunotoxicology. Springer. 2014. p. 1-11 https://doi.org/10.1007/978-3-642-27786-3_957-2