Maturation of the immune response

S.E.C. van Altena; B. Meijer; H.F.J. Savelkoul

doi:10.1007/978-3-642-27786-3_957-2

Maturation of the immune response

S.E.C. van Altena, B. Meijer, H.F.J. Savelkoul

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1ß, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...

Original language	English
Title of host publication	Encyclopedia of Immunotoxicology
Editors	H.W. Vohr
Publisher	Springer
Pages	1-11
ISBN (Print)	9783642277863
DOIs	https://doi.org/10.1007/978-3-642-27786-3_957-2 https://doi.org/10.1007/978-3-642-54596-2_957
Publication status	Published - 2014

Access to Document

Cite this

@inbook{d791438f56a042f291016153ece39656,

title = "Maturation of the immune response",

abstract = "The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1{\ss}, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...",

author = "{van Altena}, S.E.C. and B. Meijer and H.F.J. Savelkoul",

year = "2014",

doi = "10.1007/978-3-642-27786-3_957-2",

language = "English",

isbn = "9783642277863",

pages = "1--11",

editor = "H.W. Vohr",

booktitle = "Encyclopedia of Immunotoxicology",

publisher = "Springer",

address = "Germany",

}

TY - CHAP

T1 - Maturation of the immune response

AU - van Altena, S.E.C.

AU - Meijer, B.

AU - Savelkoul, H.F.J.

PY - 2014

Y1 - 2014

N2 - The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1ß, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...

AB - The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1ß, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...

U2 - 10.1007/978-3-642-27786-3_957-2

DO - 10.1007/978-3-642-27786-3_957-2

M3 - Chapter

SN - 9783642277863

SP - 1

EP - 11

BT - Encyclopedia of Immunotoxicology

A2 - Vohr, H.W.

PB - Springer

ER -

Maturation of the immune response

Abstract

Access to Document

Fingerprint

Cite this