### Abstract

Bovine reproduction and fertility is studied extensively, especially
because dairy cow fertility has declined during the last decades. The
regulation of estrus is controlled by the complex interplay of various
organs and hormones. Mathematical modeling of the bovine estrous
cycle could help in understanding the dynamics of this complex
biological system. We developed a mechanistic model of the bovine
estrous cycle that includes the processes of follicle and corpus luteum
development and the key hormones that interact to control these
processes. The model contains 12 ordinary differential equations and
51 parameters. The model generates estrous cycles of 21 days, with
three peaks of follicle stimulating hormone and three corresponding
waves of follicular growth. Progesterone, which is high during the first
two waves, decreases as the corpus luteum regresses under prostaglandin
influence. The third follicular wave results in increasing levels
of estradiol. This causes a surge of luteinizing hormone, which triggers
ovulation. Simulations show that a set of equations and parameters
was obtained that describes the system consistent with empirical data.
The model could be used as a basis for more elaborate models, that
include parameters in the field of e.g. energy metabolism, stress, and
estrous behavior.

Original language | English |
---|---|

Title of host publication | Proceedings of the 14th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Eger, Hungary, 15-18 September 2010 |

Place of Publication | Berlin |

Publisher | Blackwell Verlag |

Pages | 59-59 |

Volume | 45 |

Publication status | Published - 2010 |

Event | 14th Annual Conference of The European Society for Domestic Animal Reproduction (ESDAR), Eger, Hungary - Duration: 14 Sep 2010 → 18 Sep 2010 |

### Conference

Conference | 14th Annual Conference of The European Society for Domestic Animal Reproduction (ESDAR), Eger, Hungary |
---|---|

Period | 14/09/10 → 18/09/10 |

## Fingerprint Dive into the research topics of 'Mathematical model of the bovine estrous cycle'. Together they form a unique fingerprint.

## Cite this

Boer, H. M. T., Stötzel, C., Röblitz, S., Deuflhard, P., Veerkamp, R. F., & Woelders, H. (2010). Mathematical model of the bovine estrous cycle. In

*Proceedings of the 14th Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Eger, Hungary, 15-18 September 2010*(Vol. 45, pp. 59-59). Blackwell Verlag.