Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life

F.T. Wieringa, M.A. Dijkhuizen, Muhilal, J.W.M. van der Meer

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30 Citations (Scopus)

Abstract

Background/Objectives: Micronutrient deficiencies are prevalent worldwide, and a major cause of infant death. Supplementation with multiple micronutrients during pregnancy might improve micronutrient status of the newborn, thereby reducing morbidity and death. Moreover, maternal supplementation might affect the newborn's immune development. Therefore, this study investigated the effects of maternal zinc and beta-carotene supplementation on the infant's morbidity and immune function during the first 6 months of life. Subjects/Methods: Mothers were supplemented during pregnancy with beta-carotene and/or zinc, in addition to iron and folic acid, in a randomized, double-blind controlled trial. Newborn infants (n = 136) were followed up for 6 months. Results: Infants born from mothers receiving zinc during pregnancy had significantly fewer episodes of diarrhoea than infants born from mothers not receiving zinc (0.2 and 0.4, respectively), but more episodes of cough (1.3 and 0.9 respectively) during the first 6 months. Maternal beta-carotene supplementation had no effect on infants' morbidity. Cytokine production in the newborns was affected by maternal zinc and beta-carotene supplementation, with zinc supplementation giving higher interleukin-6 production (16% higher), and beta-carotene supplementation leading to lower interferon-g production (36% lower). Conclusions: This study shows that maternal supplementation with zinc and beta-carotene affected the newborn's immune development in specific ways, but only maternal zinc supplementation significantly affected morbidity in the infants. Addition of zinc to routine iron and folic acid supplements for pregnant women could be an effective way to reduce diarrhoeal disease during the first 6 months of life, albeit at the expense of more episodes of cough. European Journal of Clinical Nutrition (2010) 64, 1072-1079; doi:10.1038/ejcn.2010.115; published online 4 August 2010
Original languageEnglish
Pages (from-to)1072-1079
JournalEuropean Journal of Clinical Nutrition
Volume64
Issue number10
DOIs
Publication statusPublished - 2010

Fingerprint

Micronutrients
beta Carotene
Zinc
Mothers
Morbidity
Newborn Infant
Folic Acid
Cough
Pregnancy
Iron
Interferons
Pregnant Women
Cause of Death
Diarrhea
Interleukin-6
Cytokines

Keywords

  • vitamin-a supplementation
  • placebo-controlled trial
  • low-birth-weight
  • double-blind
  • indonesian infants
  • randomized-trial
  • pregnant-women
  • mortality
  • children
  • deficiency

Cite this

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title = "Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life",
abstract = "Background/Objectives: Micronutrient deficiencies are prevalent worldwide, and a major cause of infant death. Supplementation with multiple micronutrients during pregnancy might improve micronutrient status of the newborn, thereby reducing morbidity and death. Moreover, maternal supplementation might affect the newborn's immune development. Therefore, this study investigated the effects of maternal zinc and beta-carotene supplementation on the infant's morbidity and immune function during the first 6 months of life. Subjects/Methods: Mothers were supplemented during pregnancy with beta-carotene and/or zinc, in addition to iron and folic acid, in a randomized, double-blind controlled trial. Newborn infants (n = 136) were followed up for 6 months. Results: Infants born from mothers receiving zinc during pregnancy had significantly fewer episodes of diarrhoea than infants born from mothers not receiving zinc (0.2 and 0.4, respectively), but more episodes of cough (1.3 and 0.9 respectively) during the first 6 months. Maternal beta-carotene supplementation had no effect on infants' morbidity. Cytokine production in the newborns was affected by maternal zinc and beta-carotene supplementation, with zinc supplementation giving higher interleukin-6 production (16{\%} higher), and beta-carotene supplementation leading to lower interferon-g production (36{\%} lower). Conclusions: This study shows that maternal supplementation with zinc and beta-carotene affected the newborn's immune development in specific ways, but only maternal zinc supplementation significantly affected morbidity in the infants. Addition of zinc to routine iron and folic acid supplements for pregnant women could be an effective way to reduce diarrhoeal disease during the first 6 months of life, albeit at the expense of more episodes of cough. European Journal of Clinical Nutrition (2010) 64, 1072-1079; doi:10.1038/ejcn.2010.115; published online 4 August 2010",
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Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life. / Wieringa, F.T.; Dijkhuizen, M.A.; Muhilal; van der Meer, J.W.M.

In: European Journal of Clinical Nutrition, Vol. 64, No. 10, 2010, p. 1072-1079.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Maternal micronutrient supplementation with zinc and beta-carotene affects morbidity and immune function of infants during the first 6 months of life

AU - Wieringa, F.T.

AU - Dijkhuizen, M.A.

AU - Muhilal, null

AU - van der Meer, J.W.M.

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N2 - Background/Objectives: Micronutrient deficiencies are prevalent worldwide, and a major cause of infant death. Supplementation with multiple micronutrients during pregnancy might improve micronutrient status of the newborn, thereby reducing morbidity and death. Moreover, maternal supplementation might affect the newborn's immune development. Therefore, this study investigated the effects of maternal zinc and beta-carotene supplementation on the infant's morbidity and immune function during the first 6 months of life. Subjects/Methods: Mothers were supplemented during pregnancy with beta-carotene and/or zinc, in addition to iron and folic acid, in a randomized, double-blind controlled trial. Newborn infants (n = 136) were followed up for 6 months. Results: Infants born from mothers receiving zinc during pregnancy had significantly fewer episodes of diarrhoea than infants born from mothers not receiving zinc (0.2 and 0.4, respectively), but more episodes of cough (1.3 and 0.9 respectively) during the first 6 months. Maternal beta-carotene supplementation had no effect on infants' morbidity. Cytokine production in the newborns was affected by maternal zinc and beta-carotene supplementation, with zinc supplementation giving higher interleukin-6 production (16% higher), and beta-carotene supplementation leading to lower interferon-g production (36% lower). Conclusions: This study shows that maternal supplementation with zinc and beta-carotene affected the newborn's immune development in specific ways, but only maternal zinc supplementation significantly affected morbidity in the infants. Addition of zinc to routine iron and folic acid supplements for pregnant women could be an effective way to reduce diarrhoeal disease during the first 6 months of life, albeit at the expense of more episodes of cough. European Journal of Clinical Nutrition (2010) 64, 1072-1079; doi:10.1038/ejcn.2010.115; published online 4 August 2010

AB - Background/Objectives: Micronutrient deficiencies are prevalent worldwide, and a major cause of infant death. Supplementation with multiple micronutrients during pregnancy might improve micronutrient status of the newborn, thereby reducing morbidity and death. Moreover, maternal supplementation might affect the newborn's immune development. Therefore, this study investigated the effects of maternal zinc and beta-carotene supplementation on the infant's morbidity and immune function during the first 6 months of life. Subjects/Methods: Mothers were supplemented during pregnancy with beta-carotene and/or zinc, in addition to iron and folic acid, in a randomized, double-blind controlled trial. Newborn infants (n = 136) were followed up for 6 months. Results: Infants born from mothers receiving zinc during pregnancy had significantly fewer episodes of diarrhoea than infants born from mothers not receiving zinc (0.2 and 0.4, respectively), but more episodes of cough (1.3 and 0.9 respectively) during the first 6 months. Maternal beta-carotene supplementation had no effect on infants' morbidity. Cytokine production in the newborns was affected by maternal zinc and beta-carotene supplementation, with zinc supplementation giving higher interleukin-6 production (16% higher), and beta-carotene supplementation leading to lower interferon-g production (36% lower). Conclusions: This study shows that maternal supplementation with zinc and beta-carotene affected the newborn's immune development in specific ways, but only maternal zinc supplementation significantly affected morbidity in the infants. Addition of zinc to routine iron and folic acid supplements for pregnant women could be an effective way to reduce diarrhoeal disease during the first 6 months of life, albeit at the expense of more episodes of cough. European Journal of Clinical Nutrition (2010) 64, 1072-1079; doi:10.1038/ejcn.2010.115; published online 4 August 2010

KW - vitamin-a supplementation

KW - placebo-controlled trial

KW - low-birth-weight

KW - double-blind

KW - indonesian infants

KW - randomized-trial

KW - pregnant-women

KW - mortality

KW - children

KW - deficiency

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DO - 10.1038/ejcn.2010.115

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