Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects

H.P.M. Smedts, M. Rakhshandehroo, A.C. Verkleij-Hagoort, J.H.M. de Vries, J. Ottenkamp, E.A.P. Steegers, R.P.M. Steegers-Theunissen

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Abstract

With the exception of studies on folic acid, little evidence is available concerning other nutrients in the pathogenesis of congenital heart defects (CHDs). Fatty acids play a central role in embryonic development, and the B-vitamins riboflavin and nicotinamide are co-enzymes in lipid metabolism. Aim of the study To investigate associations between the maternal dietary intake of fats, riboflavin and nicotinamide, and CHD risk in the offspring. Methods A case-control family study was conducted in 276 mothers of a child with a CHD comprising of 190 outflow tract defects (OTD) and 86 non-outflow tract defects (non-OTD) and 324 control mothers of a non-malformed child. Mothers filled out general and food frequency questionnaires at 16 months after the index-pregnancy, as a proxy of the habitual food intake in the preconception period. Nutrient intakes (medians) were compared between cases and controls by Mann¿Whitney U test. Odds ratios (OR) for the association between CHDs and nutrient intakes were estimated in a logistic regression model. Results Case mothers, in particular mothers of a child with OTD, had higher dietary intakes of saturated fat, 30.9 vs. 29.8 g/d; P <0.05. Dietary intakes of riboflavin and nicotinamide were lower in mothers of a child with an OTD than in controls (1.32 vs. 1.41 mg/d; P <0.05 and 14.6 vs. 15.1 mg/d; P <0.05, respectively). Energy, unsaturated fat, cholesterol and folate intakes were comparable between the groups. Low dietary intakes of both riboflavin (
Original languageEnglish
Pages (from-to)357-365
JournalEuropean Journal of Nutrition
Volume47
Issue number7
DOIs
Publication statusPublished - 2008

Keywords

  • neural crest
  • folic-acid
  • in-vitro
  • birth-defects
  • homocysteine
  • pregnancy
  • women
  • vitamin
  • disease
  • obesity

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    Smedts, H. P. M., Rakhshandehroo, M., Verkleij-Hagoort, A. C., de Vries, J. H. M., Ottenkamp, J., Steegers, E. A. P., & Steegers-Theunissen, R. P. M. (2008). Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects. European Journal of Nutrition, 47(7), 357-365. https://doi.org/10.1007/s00394-008-0735-6