Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study

Katri Korpela, Otto Helve, Kaija Leena Kolho, Terhi Saisto, Kirsi Skogberg, Evgenia Dikareva, Vedran Stefanovic, Anne Salonen, Sture Andersson, Willem M. de Vos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A proof-of-concept safety study shows that oral fecal transplantation can shift the microbiome composition of infants who are born via cesarean section to a profile that is more similar to those born via vaginal delivery.

Original languageEnglish
Pages (from-to)324-334
JournalCell
Volume183
Issue number2
DOIs
Publication statusPublished - 15 Oct 2020

Keywords

  • cesarean section
  • clinical trial
  • colonization
  • early-life health
  • fecal microbiota transplantation
  • maternal seeding
  • microbiota development
  • newborn
  • selective outgrowth
  • vertical transmission

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