Mapping of serum amalyse-1 and quantitative trait loci for milk production traits to cattle chromosome 4.

M. Lindersson, L. Andersson-Eklund, D.J. de Koning, A. Lunden, A. Mäki-Tanila, L. Andersson

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Abstract

The present study was undertaken to confirm and refine the mapping of a quantitative trait locus in cattle for milk fat percentage that had earlier been reported to be linked to the serum amylase-1 locus, AM1. Five half-sib families from the previous study and 7 new ones were genotyped for nine microsatellite markers spanning chromosome 4. AM1 was mapped between the microsatellite markers BMS648 and BR6303. In a granddaughter design, interval mapping based on multiple-marker regression was utilized for an analysis of five milk production traits: milk yield, fat percentage and yield, and protein percentage and yield. In the families reported on previously, significant effects for fat and protein percentages were detected. In the new families, an effect on milk and fat yields was found. The most likely positions of the quantitative trait locus in both groups of families were in the same area of chromosome 4 in the vicinity of the obese locus. Direct effects of the obese locus were tested for using polymorphism in two closely linked microsatellites located 2.5 and 3.6 top downstream of the coding sequence. No firm evidence was found for an association between the obese locus and the tested traits.
Original languageEnglish
Pages (from-to)1454-1461
JournalJournal of Dairy Science
Volume81
DOIs
Publication statusPublished - 1998

Fingerprint

Chromosomes, Human, Pair 4
Quantitative Trait Loci
quantitative trait loci
milk production
Milk
Fats
Microsatellite Repeats
chromosomes
loci
cattle
microsatellite repeats
Serum
milk fat percentage
new family
milk fat yield
Amylases
lipids
amylases
Proteins
proteins

Cite this

Lindersson, M., Andersson-Eklund, L., de Koning, D. J., Lunden, A., Mäki-Tanila, A., & Andersson, L. (1998). Mapping of serum amalyse-1 and quantitative trait loci for milk production traits to cattle chromosome 4. Journal of Dairy Science, 81, 1454-1461. https://doi.org/10.3168/jds.S0022-0302(98)75709-1
Lindersson, M. ; Andersson-Eklund, L. ; de Koning, D.J. ; Lunden, A. ; Mäki-Tanila, A. ; Andersson, L. / Mapping of serum amalyse-1 and quantitative trait loci for milk production traits to cattle chromosome 4. In: Journal of Dairy Science. 1998 ; Vol. 81. pp. 1454-1461.
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abstract = "The present study was undertaken to confirm and refine the mapping of a quantitative trait locus in cattle for milk fat percentage that had earlier been reported to be linked to the serum amylase-1 locus, AM1. Five half-sib families from the previous study and 7 new ones were genotyped for nine microsatellite markers spanning chromosome 4. AM1 was mapped between the microsatellite markers BMS648 and BR6303. In a granddaughter design, interval mapping based on multiple-marker regression was utilized for an analysis of five milk production traits: milk yield, fat percentage and yield, and protein percentage and yield. In the families reported on previously, significant effects for fat and protein percentages were detected. In the new families, an effect on milk and fat yields was found. The most likely positions of the quantitative trait locus in both groups of families were in the same area of chromosome 4 in the vicinity of the obese locus. Direct effects of the obese locus were tested for using polymorphism in two closely linked microsatellites located 2.5 and 3.6 top downstream of the coding sequence. No firm evidence was found for an association between the obese locus and the tested traits.",
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Lindersson, M, Andersson-Eklund, L, de Koning, DJ, Lunden, A, Mäki-Tanila, A & Andersson, L 1998, 'Mapping of serum amalyse-1 and quantitative trait loci for milk production traits to cattle chromosome 4.', Journal of Dairy Science, vol. 81, pp. 1454-1461. https://doi.org/10.3168/jds.S0022-0302(98)75709-1

Mapping of serum amalyse-1 and quantitative trait loci for milk production traits to cattle chromosome 4. / Lindersson, M.; Andersson-Eklund, L.; de Koning, D.J.; Lunden, A.; Mäki-Tanila, A.; Andersson, L.

In: Journal of Dairy Science, Vol. 81, 1998, p. 1454-1461.

Research output: Contribution to journalArticleAcademicpeer-review

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AB - The present study was undertaken to confirm and refine the mapping of a quantitative trait locus in cattle for milk fat percentage that had earlier been reported to be linked to the serum amylase-1 locus, AM1. Five half-sib families from the previous study and 7 new ones were genotyped for nine microsatellite markers spanning chromosome 4. AM1 was mapped between the microsatellite markers BMS648 and BR6303. In a granddaughter design, interval mapping based on multiple-marker regression was utilized for an analysis of five milk production traits: milk yield, fat percentage and yield, and protein percentage and yield. In the families reported on previously, significant effects for fat and protein percentages were detected. In the new families, an effect on milk and fat yields was found. The most likely positions of the quantitative trait locus in both groups of families were in the same area of chromosome 4 in the vicinity of the obese locus. Direct effects of the obese locus were tested for using polymorphism in two closely linked microsatellites located 2.5 and 3.6 top downstream of the coding sequence. No firm evidence was found for an association between the obese locus and the tested traits.

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