Malaria parasites in mosquitoes: laboratory models, evolutionary temptation and the real world

C.H.J.J. Boëte

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Abstract

A recent study describing the effect of Plasmodium berghei infection on some Anopheles gambiae immune genes demonstrates that P. berghei is responsible for the upregulation of several genes involved in the immune response that affect parasitic development differently during the ookinete-to-oocyst developmental transition. It is important to question the relevance of such results, which are based on a laboratory model system, when discussing host-parasite interactions and, especially, the development of novel control strategies for malaria.
Original languageEnglish
Pages (from-to)445-447
JournalTrends in Parasitology
Volume21
Issue number10
DOIs
Publication statusPublished - 2005

Keywords

  • anopheles-gambiae
  • plasmodium-falciparum
  • sephadex beads
  • melanization
  • immunity
  • vector
  • virus

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