TY - JOUR
T1 - Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin
AU - Broekmans, W.
AU - Berendschot, T.T.J.M.
AU - Klopping-Ketelaars, I.A.A.
AU - de Vries, A.J.
AU - Goldbohm, R.A.
AU - Tijburg, L.B.M.
AU - Kardinaal, A.F.M.
AU - van Poppel, G.
N1 - 000177586600018
PY - 2002
Y1 - 2002
N2 - Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population.
Objective: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population.
Design: Volunteers (n = 376) aged 18¿75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance.
Results: Mean MP density in the total study group was 0.33 ± 0.15. MP density was 13% higher in men than in women (P <0.05). Serum and blood concentrations of -tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking.
Conclusion: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women
AB - Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population.
Objective: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population.
Design: Volunteers (n = 376) aged 18¿75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance.
Results: Mean MP density in the total study group was 0.33 ± 0.15. MP density was 13% higher in men than in women (P <0.05). Serum and blood concentrations of -tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking.
Conclusion: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women
KW - age-related maculopathy
KW - plasma carotenoid concentrations
KW - nutrition examination survey
KW - optical-density
KW - menstrual-cycle
KW - national-health
KW - iris color
KW - vitamin-a
KW - degeneration
KW - dietary
U2 - 10.1093/ajcn/76.3.595
DO - 10.1093/ajcn/76.3.595
M3 - Article
SN - 0002-9165
VL - 76
SP - 595
EP - 603
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3
ER -