MAAS enables cost-effective affinity adsorption

K.B. Merck, B.H. Dijkink, J.H. Schroot, J. Hanemaaijer

    Research output: Contribution to conferenceAbstract


    Membrane Assisted Adsorptive Separation (MAAS) is a separation technology in which the specifi city of adsorption and the high capacity of microfi ltration are combined in one unit operation. In the current project the usefulness of MAAS for the recovery of valuable components from complex feed-stocks is studied on the basis of an existing industrial process from the food industry: the recovery of lactoperoxidase (LPO) from acid whey. It was shown that the binding of LPO to a cation exchange adsorbent is highly selective. Adsorbent beads were cycled through a dedicated pumping system showing that agarose beads are more stable than polystyrene beads. Based on experiments and some safe assumptions the cost price for the production of LPO in a MAAS system was estimated to be ¿5¿¿10/kg (largely depending on the adsorbent price). This implies that MAAS is an economic process for relatively low to high added value ingredients (¿20¿200/kg, ROI after 14¿258 days). Finally, it was shown that MAAS is a much more effi cient recovery system than packed bed chromatography in terms of adsorbent inventory (10¿20 times less) and required fl oor space (7¿10 times less). This is tbecause the adsorbent is used much more effi ciently in a MAAS system (10 times/hr) than in a packed bed system (1 time/2¿12 hr).
    Original languageEnglish
    Publication statusPublished - 2005
    Event16th Affinity Conference -
    Duration: 14 Aug 200518 Aug 2005


    Conference16th Affinity Conference


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