Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

E. Phielix, V.B. Schrauwen-hinderling, M. Mensink, E. Lenaers, R. Meex, J. Hoeks, M.E. Kooi, E. Moonen-Kornips, J.P. Sels, M.K.C. Hesselink, P. Schrauwen

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Abstract

OBJECTIVE—A lower in vivo mitochondrial function has been reported in both type 2 diabetic patients and first-degree relatives of type 2 diabetic patients. The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients.
Original languageEnglish
Pages (from-to)2943-2949
JournalDiabetes
Volume57
Issue number11
DOIs
Publication statusPublished - 1 Nov 2008

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    Phielix, E., Schrauwen-hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J. P., Hesselink, M. K. C., & Schrauwen, P. (2008). Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients. Diabetes, 57(11), 2943-2949. https://doi.org/10.2337/db08-0391