Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

E. Phielix, V.B. Schrauwen-hinderling, M. Mensink, E. Lenaers, R. Meex, J. Hoeks, M.E. Kooi, E. Moonen-Kornips, J.P. Sels, M.K.C. Hesselink, P. Schrauwen

Research output: Contribution to journalArticleAcademicpeer-review

245 Citations (Scopus)

Abstract

OBJECTIVE—A lower in vivo mitochondrial function has been reported in both type 2 diabetic patients and first-degree relatives of type 2 diabetic patients. The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients.
Original languageEnglish
Pages (from-to)2943-2949
JournalDiabetes
Volume57
Issue number11
DOIs
Publication statusPublished - 1 Nov 2008

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