Low plasma selenium concentrations, high plasma human immunodeficiency virus load and high interleukin-6 concentrations are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in Zomba district, Malawi

M. van Lettow, C.E. West, J.W.M. van der Meer, F.T. Wieringa, R.D. Semba

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Abstract

Although anemia is common among adults with pulmonary tuberculosis and human immunodeficiency virus (HIV) infection in sub-Saharan Africa, the factors contributing to its pathogenesis have not been well characterized. Objective: To characterize the antioxidant micronutrient status, interleukin-6 (IL-6) concentrations, and HIV load in relationship with anemia in adults with pulmonary tuberculosis. Setting: Zomba district, Malawi. Methods: Erythropoietin, IL-6, plasma HIV load, and markers of micronutrient status (hemoglobin (Hb), plasma concentrations of retinol, ¿-tocopherol, carotenoids, ferritin, zinc, and selenium) were measured in 500 adults who presented with pulmonary tuberculosis in Zomba Central Hospital, Malawi. Results: Among 370 HIV-positive and 130 HIV-negative adults, the prevalence of anemia was 88 and 77%, respectively (P=0.002), and moderate to severe anemia (Hb
Original languageEnglish
Pages (from-to)526-532
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue number4
DOIs
Publication statusPublished - 2005

    Fingerprint

Keywords

  • acute-phase response
  • hiv-infection
  • iron-deficiency
  • erythropoietin
  • malnutrition
  • pathogenesis
  • coinfection
  • ferritin
  • uganda
  • damage

Cite this