Long-term impairment of social memory in the rat after social defeat is not restored by desglycinamide-vasopressin

L.G.J.E. Reijmers, K. Hoekstra, J.P.H. Burbach, J.M. van Ree, B.M. Spruijt

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Repeated social defeat followed by individual housing caused a long-term impairment of social memory in male rats. Social memory, as assessed in the social discrimination test using an intertrial interval of 3 min, was impaired for at least 8 weeks after the social defeat experience. Since social memory of male rodents depends on proper functioning of the sexually dimorphic vasopressin system, it was investigated whether a centrally active vasopressin fragment could restore the impaired social memory. Subcutaneous administration of 6 g/kg of the vasopressin fragment desglycinamide-vasopressin (VP1–8) 40 days after social defeat slightly improved social memory in both control and socially defeated rats. It is concluded that social defeat followed by individual housing caused a long-term impairment of social memory, which was not restored by treatment with VP1–8.
Original languageEnglish
Pages (from-to)145-148
JournalNeuroscience Letters
Volume305
DOIs
Publication statusPublished - 2001

Fingerprint Dive into the research topics of 'Long-term impairment of social memory in the rat after social defeat is not restored by desglycinamide-vasopressin'. Together they form a unique fingerprint.

Cite this