Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen Study

M.T. Streppel, M.C. Ocke, H.C. Boshuizen, F.J. Kok, D. Kromhout

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46 Citations (Scopus)


Aims: To assess the relationship between fish consumption or eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) intake from fish, and (sudden) coronary death. Methods and results: The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13¿0.80)] until age 80 [HR: 1.34 (0.58¿3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27¿0.78)]. Conclusion: The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose¿response relationship between EPA+DHA intake and (sudden) coronary death.
Original languageEnglish
Pages (from-to)2024-2030
JournalEuropean Heart Journal
Issue number16
Publication statusPublished - 2008


  • middle-aged men
  • cardiac death
  • risk-factors
  • cardiovascular-disease
  • myocardial-infarction
  • time-scale
  • mortality
  • prevention
  • metaanalysis
  • mechanism


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