Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Tamara Hoppenbrouwers, Jelena H. Cvejić Hogervorst, Johan Garssen, Harry J. Wichers, Linette E.M. Willemsen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An "inflammation-suppressive" effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical, in vivo and in vitro studies. Furthermore, we discuss the susceptibility of LCPUFAs to lipid oxidation and possible strategies to support the efficacy of LCPUFAs in reducing the allergy risk by using additional components with anti-oxidative and anti-inflammatory capacities such as the flavonoid quercetin. Finally, we propose new strategies to prevent (food) allergy using combinations of LCPUFAs and additional nutrients in diets or supplements, and postulate to investigate the use of LCPUFAs in allergic symptom relief.

Original languageEnglish
Number of pages1
JournalFrontiers in Immunology
Volume10
DOIs
Publication statusPublished - 22 May 2019

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Food Hypersensitivity
Unsaturated Fatty Acids
Anti-Allergic Agents
Immune System Diseases
Quercetin
Omega-3 Fatty Acids
Flavonoids
Hypersensitivity
Anti-Inflammatory Agents
Diet
Inflammation
Lipids
Food
Health

Keywords

  • anti-inflammatory
  • food allergy
  • immune response
  • LCPUFA
  • PUFA

Cite this

Hoppenbrouwers, Tamara ; Cvejić Hogervorst, Jelena H. ; Garssen, Johan ; Wichers, Harry J. ; Willemsen, Linette E.M. / Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy. In: Frontiers in Immunology. 2019 ; Vol. 10.
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Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy. / Hoppenbrouwers, Tamara; Cvejić Hogervorst, Jelena H.; Garssen, Johan; Wichers, Harry J.; Willemsen, Linette E.M.

In: Frontiers in Immunology, Vol. 10, 22.05.2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

AU - Hoppenbrouwers, Tamara

AU - Cvejić Hogervorst, Jelena H.

AU - Garssen, Johan

AU - Wichers, Harry J.

AU - Willemsen, Linette E.M.

PY - 2019/5/22

Y1 - 2019/5/22

N2 - N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An "inflammation-suppressive" effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical, in vivo and in vitro studies. Furthermore, we discuss the susceptibility of LCPUFAs to lipid oxidation and possible strategies to support the efficacy of LCPUFAs in reducing the allergy risk by using additional components with anti-oxidative and anti-inflammatory capacities such as the flavonoid quercetin. Finally, we propose new strategies to prevent (food) allergy using combinations of LCPUFAs and additional nutrients in diets or supplements, and postulate to investigate the use of LCPUFAs in allergic symptom relief.

AB - N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An "inflammation-suppressive" effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical, in vivo and in vitro studies. Furthermore, we discuss the susceptibility of LCPUFAs to lipid oxidation and possible strategies to support the efficacy of LCPUFAs in reducing the allergy risk by using additional components with anti-oxidative and anti-inflammatory capacities such as the flavonoid quercetin. Finally, we propose new strategies to prevent (food) allergy using combinations of LCPUFAs and additional nutrients in diets or supplements, and postulate to investigate the use of LCPUFAs in allergic symptom relief.

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KW - food allergy

KW - immune response

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KW - PUFA

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SN - 1664-3224

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