Localization of candidate allergen genes on the apple (Malus domestica) genome and their putative allergenicity

Gao Zhongshan

Research output: Thesisexternal PhD, WU

Abstract

Apple is generally considered as a healthy food, but 2-3% European people can not eat this fruit because it provokes allergy reaction. Four classes of apple allergen genes have been identified, they are Mal d 1, Mal d 2, Mal d 3 and Mal d 4 . This thesis focuses on the genomic characterization of these candidate genes on the apple genome by linkage mapping through sequence-specific DNA markers. In total, 26 putative Mal d genes, 25 of them were mapped on 8 linkage groups:17 for Mal d 1 , two for Mal d 2 and Mal d 3 , and four for Mal d 4 .As for the patients in northern and central Europe, the major apple allergen is Mal d 1. Genetic analysis demonstrated the Mal d 1 genes on linkage group (Chromosomes) 16 are relevant. Furthermore, a molecular marker linked to low-Mal d 1 allergenic trait was identified.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Jacobsen, Evert, Promotor
  • Visser, Richard, Promotor
  • van de Weg, Eric, Co-promotor
  • Gilissen, Luud, Co-promotor
Award date30 Jun 2005
Place of PublicationWageningen
Print ISBNs9789085042426
DOIs
Publication statusPublished - 30 Jun 2005

Keywords

  • apples
  • malus pumila
  • allergens
  • genomes
  • genes
  • allergies
  • allergic reactions
  • food allergies
  • plant breeding
  • varieties
  • dna sequencing
  • genomics

Fingerprint

Dive into the research topics of 'Localization of candidate allergen genes on the apple (Malus domestica) genome and their putative allergenicity'. Together they form a unique fingerprint.

Cite this