Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection

Bart Cortjens*, Rineke de Jong, Judith G. Bonsing, Job B.M. Van Woensel, Adriaan F.G. Antonis, Reinout A. Bem

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Respiratory syncytial virus (RSV) infection is characterised by airway obstruction with mucus plugs, containing DNA networks in the form of neutrophil extracellular traps (NETs). We investigated the effect of dornase alfa on histopathological NETs-induced airway obstruction and viral load in an age-relevant calf model of severe bovine RSV disease. As compared with the control animals, dornase alfa treatment resulted in a strong reduction of NETs-induced airway obstruction. Viral load in the lower respiratory tract was not different between the two groups. We conclude that NETs form a relevant target for treatment of airway obstruction in severe RSV disease.

Original languageEnglish
Pages (from-to)578-580
JournalThorax
Volume73
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • infection control
  • innate immunity
  • neutrophil biology
  • paediatric lung disaese
  • respiratory infection
  • viral infection

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