Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017

Marjolein J. Poen, Theo M. Bestebroer, Oanh Vuong, Rachel D. Scheuer, Henk P. van der Jeugd, Erik Kleyheeg, Dirk Eggink, Pascal Lexmond, Judith M.A. van den Brand, Lineke Begeman, Stefan van der Vliet, Gerhard J.D.M. Müskens, Frank A. Majoor, Marion P.G. Koopmans, Thijs Kuiken, Ron A.M. Fouchier

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Abstract

Introduction: Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were re-introduced into the Netherlands by late 2016, after detections in southeast Asia and Russia. This second H5N8 wave resulted in a large number of outbreaks in poultry farms and the deaths of large numbers of wild birds in multiple European countries. Methods: Here we report on the detection of HPAI H5N8 virus in 57 wild birds of 12 species sampled during active (32/5,167) and passive (25/36) surveillance activities, i.e. in healthy and dead animals respectively, in the Netherlands between 8 November 2016 and 31 March 2017. Moreover, we further investigate the experimental approach of wild bird serology as a contributing tool in HPAI outbreak investigations. Results: In contrast to the first H5N8 wave, local virus amplification with associated wild bird mortality has occurred in the Netherlands in 2016/17, with evidence for occasional gene exchange with low pathogenic avian influenza (LPAI) viruses. Discussion: These apparent differences between outbreaks and the continuing detections of HPAI viruses in Europe are a cause of concern. With the current circulation of zoonotic HPAI and LPAI virus strains in Asia, increased understanding of the drivers responsible for the global spread of Asian poultry viruses via wild birds is needed.
LanguageEnglish
Article number17-00449
JournalEurosurveillance
Volume23
Issue number4
DOIs
Publication statusPublished - 25 Jan 2018

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Influenza in Birds
Orthomyxoviridae
Netherlands
Birds
Disease Outbreaks
Poultry
Viruses
Southeastern Asia
Russia
Zoonoses
Serology
H5N8 Subtype Influenza A Virus
Mortality
Genes

Cite this

Poen, M. J., Bestebroer, T. M., Vuong, O., Scheuer, R. D., van der Jeugd, H. P., Kleyheeg, E., ... Fouchier, R. A. M. (2018). Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. Eurosurveillance, 23(4), [17-00449]. https://doi.org/10.2807/1560-7917.ES.2018.23.4.17-00449
Poen, Marjolein J. ; Bestebroer, Theo M. ; Vuong, Oanh ; Scheuer, Rachel D. ; van der Jeugd, Henk P. ; Kleyheeg, Erik ; Eggink, Dirk ; Lexmond, Pascal ; van den Brand, Judith M.A. ; Begeman, Lineke ; van der Vliet, Stefan ; Müskens, Gerhard J.D.M. ; Majoor, Frank A. ; Koopmans, Marion P.G. ; Kuiken, Thijs ; Fouchier, Ron A.M. / Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. In: Eurosurveillance. 2018 ; Vol. 23, No. 4.
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title = "Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017",
abstract = "Introduction: Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were re-introduced into the Netherlands by late 2016, after detections in southeast Asia and Russia. This second H5N8 wave resulted in a large number of outbreaks in poultry farms and the deaths of large numbers of wild birds in multiple European countries. Methods: Here we report on the detection of HPAI H5N8 virus in 57 wild birds of 12 species sampled during active (32/5,167) and passive (25/36) surveillance activities, i.e. in healthy and dead animals respectively, in the Netherlands between 8 November 2016 and 31 March 2017. Moreover, we further investigate the experimental approach of wild bird serology as a contributing tool in HPAI outbreak investigations. Results: In contrast to the first H5N8 wave, local virus amplification with associated wild bird mortality has occurred in the Netherlands in 2016/17, with evidence for occasional gene exchange with low pathogenic avian influenza (LPAI) viruses. Discussion: These apparent differences between outbreaks and the continuing detections of HPAI viruses in Europe are a cause of concern. With the current circulation of zoonotic HPAI and LPAI virus strains in Asia, increased understanding of the drivers responsible for the global spread of Asian poultry viruses via wild birds is needed.",
author = "Poen, {Marjolein J.} and Bestebroer, {Theo M.} and Oanh Vuong and Scheuer, {Rachel D.} and {van der Jeugd}, {Henk P.} and Erik Kleyheeg and Dirk Eggink and Pascal Lexmond and {van den Brand}, {Judith M.A.} and Lineke Begeman and {van der Vliet}, Stefan and M{\"u}skens, {Gerhard J.D.M.} and Majoor, {Frank A.} and Koopmans, {Marion P.G.} and Thijs Kuiken and Fouchier, {Ron A.M.}",
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Poen, MJ, Bestebroer, TM, Vuong, O, Scheuer, RD, van der Jeugd, HP, Kleyheeg, E, Eggink, D, Lexmond, P, van den Brand, JMA, Begeman, L, van der Vliet, S, Müskens, GJDM, Majoor, FA, Koopmans, MPG, Kuiken, T & Fouchier, RAM 2018, 'Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017', Eurosurveillance, vol. 23, no. 4, 17-00449. https://doi.org/10.2807/1560-7917.ES.2018.23.4.17-00449

Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. / Poen, Marjolein J.; Bestebroer, Theo M.; Vuong, Oanh; Scheuer, Rachel D.; van der Jeugd, Henk P.; Kleyheeg, Erik; Eggink, Dirk; Lexmond, Pascal; van den Brand, Judith M.A.; Begeman, Lineke; van der Vliet, Stefan; Müskens, Gerhard J.D.M.; Majoor, Frank A.; Koopmans, Marion P.G.; Kuiken, Thijs; Fouchier, Ron A.M.

In: Eurosurveillance, Vol. 23, No. 4, 17-00449, 25.01.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017

AU - Poen, Marjolein J.

AU - Bestebroer, Theo M.

AU - Vuong, Oanh

AU - Scheuer, Rachel D.

AU - van der Jeugd, Henk P.

AU - Kleyheeg, Erik

AU - Eggink, Dirk

AU - Lexmond, Pascal

AU - van den Brand, Judith M.A.

AU - Begeman, Lineke

AU - van der Vliet, Stefan

AU - Müskens, Gerhard J.D.M.

AU - Majoor, Frank A.

AU - Koopmans, Marion P.G.

AU - Kuiken, Thijs

AU - Fouchier, Ron A.M.

PY - 2018/1/25

Y1 - 2018/1/25

N2 - Introduction: Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were re-introduced into the Netherlands by late 2016, after detections in southeast Asia and Russia. This second H5N8 wave resulted in a large number of outbreaks in poultry farms and the deaths of large numbers of wild birds in multiple European countries. Methods: Here we report on the detection of HPAI H5N8 virus in 57 wild birds of 12 species sampled during active (32/5,167) and passive (25/36) surveillance activities, i.e. in healthy and dead animals respectively, in the Netherlands between 8 November 2016 and 31 March 2017. Moreover, we further investigate the experimental approach of wild bird serology as a contributing tool in HPAI outbreak investigations. Results: In contrast to the first H5N8 wave, local virus amplification with associated wild bird mortality has occurred in the Netherlands in 2016/17, with evidence for occasional gene exchange with low pathogenic avian influenza (LPAI) viruses. Discussion: These apparent differences between outbreaks and the continuing detections of HPAI viruses in Europe are a cause of concern. With the current circulation of zoonotic HPAI and LPAI virus strains in Asia, increased understanding of the drivers responsible for the global spread of Asian poultry viruses via wild birds is needed.

AB - Introduction: Highly pathogenic avian influenza (HPAI) viruses of subtype H5N8 were re-introduced into the Netherlands by late 2016, after detections in southeast Asia and Russia. This second H5N8 wave resulted in a large number of outbreaks in poultry farms and the deaths of large numbers of wild birds in multiple European countries. Methods: Here we report on the detection of HPAI H5N8 virus in 57 wild birds of 12 species sampled during active (32/5,167) and passive (25/36) surveillance activities, i.e. in healthy and dead animals respectively, in the Netherlands between 8 November 2016 and 31 March 2017. Moreover, we further investigate the experimental approach of wild bird serology as a contributing tool in HPAI outbreak investigations. Results: In contrast to the first H5N8 wave, local virus amplification with associated wild bird mortality has occurred in the Netherlands in 2016/17, with evidence for occasional gene exchange with low pathogenic avian influenza (LPAI) viruses. Discussion: These apparent differences between outbreaks and the continuing detections of HPAI viruses in Europe are a cause of concern. With the current circulation of zoonotic HPAI and LPAI virus strains in Asia, increased understanding of the drivers responsible for the global spread of Asian poultry viruses via wild birds is needed.

U2 - 10.2807/1560-7917.ES.2018.23.4.17-00449

DO - 10.2807/1560-7917.ES.2018.23.4.17-00449

M3 - Article

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JO - Eurosurveillance

T2 - Eurosurveillance

JF - Eurosurveillance

SN - 1025-496X

IS - 4

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