Live recombinant BHV/BRSV vaccine

G.M. Keil (Inventor), F.A.M. Rijsewijk (Inventor)

    Research output: PatentOther research output

    Abstract

    The present invention refers to synthetic Bovine Respiratory Syncytium virus genes. Also the invention relates to live attenuated Bovine Herpesvirus recombinants carrying such synthetic genes. Furthermore, the invention relates to vaccines based on these live attenuated recombinants, for the protection of cattle against both Bovine herpesvirus infection and against Bovine Respiratory Syncytium virus infection. Also the invention relates to methods for the preparation of such live attenuated recombinants and to methods for the preparation of such vaccines. Furthermore, the invention relates to live Bovine herpesvirus recombinant particles carrying a class II membrane glycoprotein and to live Bovine herpesvirus recombinants carrying a heterologous gene fused to a class II membrane glycoprotein membrane anchor, to vaccines based thereon, and to methods for the preparation of such recombinants, such particles and such vaccines.
    Original languageEnglish
    Patent numberWO9804710
    Priority date26/07/96
    Publication statusPublished - 5 Feb 1998

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