The present invention refers to synthetic Bovine Respiratory Syncytium virus genes. Also the invention relates to live attenuated Bovine Herpesvirus recombinants carrying such synthetic genes. Furthermore, the invention relates to vaccines based on these live attenuated recombinants, for the protection of cattle against both Bovine herpesvirus infection and against Bovine Respiratory Syncytium virus infection. Also the invention relates to methods for the preparation of such live attenuated recombinants and to methods for the preparation of such vaccines. Furthermore, the invention relates to live Bovine herpesvirus recombinant particles carrying a class II membrane glycoprotein and to live Bovine herpesvirus recombinants carrying a heterologous gene fused to a class II membrane glycoprotein membrane anchor, to vaccines based thereon, and to methods for the preparation of such recombinants, such particles and such vaccines.
|Publication status||Published - 5 Feb 1998|