Literature review on the role of dietary protein and amino acids in cognitive functioning and cognitive decline

O. van de Rest, N.L. van der Zwaluw, C.P.G.M. de Groot

Research output: Contribution to journalReview articleAcademicpeer-review

24 Citations (Scopus)

Abstract

As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on dietary protein and cognitive functioning and cognitive decline. Also studies on the individual amino acids that are related to brain function, tryptophan and tyrosine, are discussed. Overall, the role of dietary protein intake on cognitive functioning as well as cognitive decline has hardly been studied; we found eight observational studies and three intervention studies. More studies investigated the role of tryptophan (14 studies) and tyrosine (nine studies) in relation to cognitive functioning, but all these studies were performed in young adult populations and mostly under special conditions. Research in elderly populations, in particular, is warranted. Also more research is needed to come to definitive conclusions and specific recommendations regarding protein intake or intake of specific amino acids for maintaining optimal cognitive functioning
Original languageEnglish
Pages (from-to)1035-1045
JournalAmino Acids
Volume45
Issue number5
DOIs
Publication statusPublished - 2013

Fingerprint

Dietary Proteins
Tryptophan
Tyrosine
Amino Acids
Nutrition
Brain
Population
Research
Observational Studies
Dementia
Young Adult
Proteins
Diet
Cognitive Dysfunction

Keywords

  • alpha-lactalbumin increases
  • nutritional-status
  • working-memory
  • l-tryptophan
  • alzheimers-disease
  • plasma tryptophan
  • elderly-people
  • sleep-deprivation
  • motor-performance
  • carbohydrate-rich

Cite this

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title = "Literature review on the role of dietary protein and amino acids in cognitive functioning and cognitive decline",
abstract = "As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on dietary protein and cognitive functioning and cognitive decline. Also studies on the individual amino acids that are related to brain function, tryptophan and tyrosine, are discussed. Overall, the role of dietary protein intake on cognitive functioning as well as cognitive decline has hardly been studied; we found eight observational studies and three intervention studies. More studies investigated the role of tryptophan (14 studies) and tyrosine (nine studies) in relation to cognitive functioning, but all these studies were performed in young adult populations and mostly under special conditions. Research in elderly populations, in particular, is warranted. Also more research is needed to come to definitive conclusions and specific recommendations regarding protein intake or intake of specific amino acids for maintaining optimal cognitive functioning",
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author = "{van de Rest}, O. and {van der Zwaluw}, N.L. and {de Groot}, C.P.G.M.",
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Literature review on the role of dietary protein and amino acids in cognitive functioning and cognitive decline. / van de Rest, O.; van der Zwaluw, N.L.; de Groot, C.P.G.M.

In: Amino Acids, Vol. 45, No. 5, 2013, p. 1035-1045.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

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AU - van de Rest, O.

AU - van der Zwaluw, N.L.

AU - de Groot, C.P.G.M.

PY - 2013

Y1 - 2013

N2 - As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on dietary protein and cognitive functioning and cognitive decline. Also studies on the individual amino acids that are related to brain function, tryptophan and tyrosine, are discussed. Overall, the role of dietary protein intake on cognitive functioning as well as cognitive decline has hardly been studied; we found eight observational studies and three intervention studies. More studies investigated the role of tryptophan (14 studies) and tyrosine (nine studies) in relation to cognitive functioning, but all these studies were performed in young adult populations and mostly under special conditions. Research in elderly populations, in particular, is warranted. Also more research is needed to come to definitive conclusions and specific recommendations regarding protein intake or intake of specific amino acids for maintaining optimal cognitive functioning

AB - As the population of elderly people is growing rapidly, the number of individuals with dementia and cognitive impairment is also increasing. One of the preventive measures against cognitive decline is diet and different dietary factors have already been investigated. This review provides an overview of studies on dietary protein and cognitive functioning and cognitive decline. Also studies on the individual amino acids that are related to brain function, tryptophan and tyrosine, are discussed. Overall, the role of dietary protein intake on cognitive functioning as well as cognitive decline has hardly been studied; we found eight observational studies and three intervention studies. More studies investigated the role of tryptophan (14 studies) and tyrosine (nine studies) in relation to cognitive functioning, but all these studies were performed in young adult populations and mostly under special conditions. Research in elderly populations, in particular, is warranted. Also more research is needed to come to definitive conclusions and specific recommendations regarding protein intake or intake of specific amino acids for maintaining optimal cognitive functioning

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KW - l-tryptophan

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KW - plasma tryptophan

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KW - sleep-deprivation

KW - motor-performance

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