Liquid chromatography-isotope ratio mass spectrometry in food residue control

Research output: Contribution to conferencePosterAcademic


Residues that can also have an endogenous origin, need confirmative testing by carbon isotope ratio analysis. For this, gas chromatography-combustion-isotope ratio mass spectrometry (GC-c-IRMS) was traditionally used within Wageningen Food Safety Research (WFSR). However, GC-c-IRMS is often not applicable for nonvolatile’s or require derivatisation. To overcome this limitation for non-volatile’s, liquid chromatographyisotope ratio mass spectrometry (LC-IRMS) can be used. This is a challenge, as the interface design between LC and IRMS requires the need for carbon-free eluents, thereby limiting usable LC separation techniques. Here we present preliminary results using LC-IRMS as a confirmatory technique for endogenous and/or exogenous steroids, antipyretics and thyreostats.
Original languageEnglish
Number of pages1
Publication statusPublished - 23 May 2022
EventEuroResidue Conference IX 2022 - Hotel de Ruwenberg, St. Michielsgestel, Netherlands
Duration: 23 May 202225 May 2022


ConferenceEuroResidue Conference IX 2022
CitySt. Michielsgestel
Internet address


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