Liquid chromatographic method for nicarbazin in broiler feeds and premixtures: development, validation and interlaboratory study

J. de Jong, M.J.H. Tomassen, J.J.M. Driessen, H.A. Putzka, G. Brambilla

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

A reversed-phase liquid chromatography method for nicarbazin in broiler feeds and premixtures was developed, validated, and interlaboratory studied. The extraction solvent was an acetonitrile-methanol (1 + 1) mixture. For feedingstuffs, water was also added. The 4,4'-dinitrocarbanilide moiety of nicarbazin was detected at a wavelength of 350 nm. Recovery was > or =87%. At 20 mg/kg, the repeatability was 0.7% and the within-laboratory reproducibility was 2.7%. The limit of determination was
Original languageEnglish
Pages (from-to)1269-1277
JournalJournal of AOAC International
Volume87
Issue number6
Publication statusPublished - 2004

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