Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice

H. Wei, C. Hu, M. Wang, A.M. van den Hoek, T.H. Reijmers, S. Wopereis, J. Bouwman, R. Ramaker, H.A.A.J. Korthout, M. Vennik, T. Hankemeier, L.M. Havekes, R.F. Witkamp, E.R. Verheij, G. Xu, J. de Greef

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p <0.001), CETP levels (-31%, p
Original languageEnglish
Article numbere30332
JournalPLoS ONE
Volume7
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Biochemistry
rimonabant
metabolic syndrome
biochemistry
mice
apolipoprotein E3
Medicine
medicine
cholesteryl ester transfer protein
Apolipoprotein E3
Cannabinoid Receptor Antagonists
Cholesterol Ester Transfer Proteins
Plasmas
Cannabinoid Receptors
Systems Biology
hypercholesterolemia
Apolipoproteins E
Systems Analysis
Hypercholesterolemia
Liver

Keywords

  • cholesteryl ester transfer
  • systems biology
  • apoe-asterisk-3-leiden.cetp mice
  • aggravates atherosclerosis
  • overweight patients
  • chinese medicine
  • weight-reduction
  • transfer protein
  • hdl-cholesterol
  • transgenic mice

Cite this

Wei, H., Hu, C., Wang, M., van den Hoek, A. M., Reijmers, T. H., Wopereis, S., ... de Greef, J. (2012). Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice. PLoS ONE, 7(1), [e30332]. https://doi.org/10.1371/journal.pone.0030332
Wei, H. ; Hu, C. ; Wang, M. ; van den Hoek, A.M. ; Reijmers, T.H. ; Wopereis, S. ; Bouwman, J. ; Ramaker, R. ; Korthout, H.A.A.J. ; Vennik, M. ; Hankemeier, T. ; Havekes, L.M. ; Witkamp, R.F. ; Verheij, E.R. ; Xu, G. ; de Greef, J. / Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice. In: PLoS ONE. 2012 ; Vol. 7, No. 1.
@article{8f2b64670d1f4b3a81c245f06a6e90ad,
title = "Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice",
abstract = "Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49{\%}, p <0.001), CETP levels (-31{\%}, p",
keywords = "cholesteryl ester transfer, systems biology, apoe-asterisk-3-leiden.cetp mice, aggravates atherosclerosis, overweight patients, chinese medicine, weight-reduction, transfer protein, hdl-cholesterol, transgenic mice",
author = "H. Wei and C. Hu and M. Wang and {van den Hoek}, A.M. and T.H. Reijmers and S. Wopereis and J. Bouwman and R. Ramaker and H.A.A.J. Korthout and M. Vennik and T. Hankemeier and L.M. Havekes and R.F. Witkamp and E.R. Verheij and G. Xu and {de Greef}, J.",
year = "2012",
doi = "10.1371/journal.pone.0030332",
language = "English",
volume = "7",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

Wei, H, Hu, C, Wang, M, van den Hoek, AM, Reijmers, TH, Wopereis, S, Bouwman, J, Ramaker, R, Korthout, HAAJ, Vennik, M, Hankemeier, T, Havekes, LM, Witkamp, RF, Verheij, ER, Xu, G & de Greef, J 2012, 'Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice' PLoS ONE, vol. 7, no. 1, e30332. https://doi.org/10.1371/journal.pone.0030332

Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice. / Wei, H.; Hu, C.; Wang, M.; van den Hoek, A.M.; Reijmers, T.H.; Wopereis, S.; Bouwman, J.; Ramaker, R.; Korthout, H.A.A.J.; Vennik, M.; Hankemeier, T.; Havekes, L.M.; Witkamp, R.F.; Verheij, E.R.; Xu, G.; de Greef, J.

In: PLoS ONE, Vol. 7, No. 1, e30332, 2012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice

AU - Wei, H.

AU - Hu, C.

AU - Wang, M.

AU - van den Hoek, A.M.

AU - Reijmers, T.H.

AU - Wopereis, S.

AU - Bouwman, J.

AU - Ramaker, R.

AU - Korthout, H.A.A.J.

AU - Vennik, M.

AU - Hankemeier, T.

AU - Havekes, L.M.

AU - Witkamp, R.F.

AU - Verheij, E.R.

AU - Xu, G.

AU - de Greef, J.

PY - 2012

Y1 - 2012

N2 - Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p <0.001), CETP levels (-31%, p

AB - Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses. Methodology/Principal Findings: ApoE*3Leiden.CETP mice with mild hypercholesterolemia were divided into SUB885C-, rimonabant- and non-treated control groups. SUB885C caused no weight loss, but significantly reduced plasma cholesterol (-49%, p <0.001), CETP levels (-31%, p

KW - cholesteryl ester transfer

KW - systems biology

KW - apoe-asterisk-3-leiden.cetp mice

KW - aggravates atherosclerosis

KW - overweight patients

KW - chinese medicine

KW - weight-reduction

KW - transfer protein

KW - hdl-cholesterol

KW - transgenic mice

U2 - 10.1371/journal.pone.0030332

DO - 10.1371/journal.pone.0030332

M3 - Article

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 1

M1 - e30332

ER -